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Increased choline acetyltransferase activity by Chinese herbal medicine Sho-saiko-to-go-keishi-ka-shakuyaku-to in aged rat brain

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Abstract

The effect of a Chinese herbal medicine Sho-saiko-to-go-keishi-ka-shakuyaku-to (TJ-960) on the brain choline acetyltransferase (CAT) activity was studied in adult (3.5 months of age) and aged (24 months of age) rats. After oral administration of 5% TJ-960 solution for 3 months, CAT activity in the hippocampus, pons-medulla oblongata and striatum of aged rats was significantly lower than that of adult rats. CAT activity in the cerebellum, however, was significantly higher in the aged rats, as compared to the adult rats. TJ-960 significantly increased CAT activity in the hippocampus and striatum of aged rats, but did not affect the activity of the enzyme in the adult rat brain.

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Authors and Affiliations

  1. Department of Neurochemistry, Institute for Neurobiology, Okayama University Medical School, 2-5-1 Shikata-cho, 700, Okayama, Japan

    Midori Hiramatsu, Kumiko Haba, Rei Edamatsu, Hajime Hamada & Akitane Mori

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  1. Midori Hiramatsu
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  2. Kumiko Haba
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  3. Rei Edamatsu
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  4. Hajime Hamada
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  5. Akitane Mori
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Hiramatsu, M., Haba, K., Edamatsu, R. et al. Increased choline acetyltransferase activity by Chinese herbal medicine Sho-saiko-to-go-keishi-ka-shakuyaku-to in aged rat brain. Neurochem Res 14, 249–251 (1989). https://doi.org/10.1007/BF00971319

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  • DOI: https://doi.org/10.1007/BF00971319

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