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Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age

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Abstract

In the present study, we have assayed the enzymatic activity of Cu,Zn−SOD, Mn−SOD, GSH−Px, GSH-Red, Cat, and G6PD in rat retina as a function of age. Conjugated diene levels and MDA formation were also determined. The conjugated diene levels in rat retina were found to increase significantly with age, accompanied by a marked decrease in GSH−Px and Cat activities. No agerelated change in MDA levels and in GSH-Red and G6PD activity was found, whereas a significant increase in SOD activity was observed between 1 and 4 months. Decreased GSH−Px and Cat activity is related to increased lipid peroxidation with age.

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Authors and Affiliations

  1. Institute of Biochemistry, University of Catania, Viale Andrea Doria, 6, Catania, Italy

    C. Castorina, A. Campisi, C. Di Giacomo, V. Sorrenti, A. Russo & A. Vanella (Chair of Biochemistry)

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  1. C. Castorina
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  2. A. Campisi
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Castorina, C., Campisi, A., Di Giacomo, C. et al. Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age. Neurochem Res 17, 599–604 (1992). https://doi.org/10.1007/BF00968789

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