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Neuronal cell cultures: A tool for investigations in developmental neurobiology

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Abstract

The aim of this review is to describe environmental requirements for survival of neuronal cells in culture, and secondly to survey the complex interplay between hormones, neurotrophic factors, transport- and extracellular matrix- proteins, which characterize the developmental program of differentiating neurons. An overall reconsideration of the literature in this vast field is above the limits of the present paper; since progress and refinement in the techniques of neuronal cell cultures have paralleled the advancement in Developmental Neurobiology, we will run instead through the main steps which form the conceptual framework of neuronal cell cultures.

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Authors and Affiliations

  1. Clinica Neurologica, University of Palermo, Palermo, Italy

    Giovanni Savettieri & Giuseppe Salemi

  2. Dipartimento di Biologia Cellulare e dello Sviluppo “Alberto Monroy”, via Archirafi 22, 90123, Palermo, Italy

    Alessandro Cestelli & Italia Di Liegro

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  1. Alessandro Cestelli
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Cestelli, A., Savettieri, G., Salemi, G. et al. Neuronal cell cultures: A tool for investigations in developmental neurobiology. Neurochem Res 17, 1163–1180 (1992). https://doi.org/10.1007/BF00968395

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