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Stimulation of carnitine acetyltransferase in PC12 cells by nerve growth factor: Relationship to choline acetyltransferase stimulation

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Abstract

The activity of carnitine acetyltransferase (acetyl-CoA:L-carnitine O-acetyltransferase) was found to be at least 50-fold higher than that of choline acetyltransferase in PC12 cells. Nerve growth factor stimulated both enzymes in a parallel manner with respect to concentration of NGF and culture time. The stimulation of both enzymes was completely inhibited by 10 μM 6-thioguanine, an inhibitor of protein kinase N. Results are discussed with reference to the hypothesis that the two enzymes may be functionally related in neuronal cells.

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Authors and Affiliations

  1. Div. of Pharmacology, Wellcome Research Laboratories, 27709, Research Triangle Park, North Carolina

    Helen L. White & Philip W. Scates

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  1. Helen L. White
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  2. Philip W. Scates
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White, H.L., Scates, P.W. Stimulation of carnitine acetyltransferase in PC12 cells by nerve growth factor: Relationship to choline acetyltransferase stimulation. Neurochem Res 16, 63–66 (1991). https://doi.org/10.1007/BF00965829

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  • DOI: https://doi.org/10.1007/BF00965829

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