Skip to main content
SpringerLink
Log in

Antagonism of phencyclidine-induced hyperactivity by glycine in mice

  • Original Articles
  • Published:
Neurochemical Research Aims and scope Submit manuscript

Abstract

We tested the effect of glycine on phencyclidine (PCP)-induced hyperactivity in mice. Glycine antagonized the locomotor stimulating effect of PCP. Correlation was found between the degree of antagonistic effect and the size of the increase in glycine in the brain. The antagonism is not due to changes in uptake, since the elevation of glycine in plasma and brain had no effect on the cerebral uptake of PCP. This pharmacological action of glycine appears to be a central effect, but some peripheral effect can not be excluded. Since glycine is not toxic at levels needed for PCP antagonism, it could be considered for ameliorating PCP psychosis. The locomotor stimulating effect of PCP is strain dependent in mouse. Some strains are responsive, such as BALB/cBy and CXBK, and some are unresponsive, such as C57BL/6 and CXBH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Allen, R. M., Young, S. J. 1978. Phencyclidine-induced psychosis. Am. J. Psychiat. 135:1081–1084.

    PubMed  Google Scholar 

  2. Castellani, S., andAdams, P. M. 1981. Acute and chronic phencyclidine effects on locomotor activity, stereotypy and ataxia in rats. Eur. J. Pharmacol. 73:143.

    PubMed  Google Scholar 

  3. Lozovsky, D., Saller, C. F., Bayorh, M. A., Chiueh, C. C., Ric, K. C., Burke, T. R., andKopin, J. J., 1983. Effects of phencyclidine on rat prolactin, dopamine receptor and locomotor activity. Life Sci. 32:2725–2731.

    PubMed  Google Scholar 

  4. Snyder, S. H. 1980. Phencyclidine. Nature 285:355–356.

    PubMed  Google Scholar 

  5. Castellani, S., Giannini, J. A., andAdams, P. M. 1982. Physostigmine and haloperidol treatment of acute phencyclidine intoxication. Am. J. Psychiat. 139:508–510.

    PubMed  Google Scholar 

  6. Freed, W. J., Weinberger, D. R., Bing, L. A., andWyatt, R. J. 1980. Neuropharmacological studies of phencyclidine (PCP)-induced behavioral stimulation in mice. Psychopharmacology 71:291–297.

    PubMed  Google Scholar 

  7. Freed, W. J., Bing, L. A., andWyatt, R. J. 1984. Effects of neuroleptics on phencyclidine (PCP)-induced locomotor stimulation in mice. Neuropharmacology 23:175–181.

    PubMed  Google Scholar 

  8. Chaturvedi, A. K. 1984. Effects of mecamylamine, nicotine, atropine and physostigmine on the phencyclidine-induced behavioral toxicity. Pharmacol. Biochem. Behav. 20:559–566.

    PubMed  Google Scholar 

  9. Smith, C. R., Meltzer, H. Y., Arora, R. C., andDavis, M. J. 1977. Effects of phencyclidine on [3H]catecholamine and [3H]serotonin uptake in synaptosomal preparations from rat brain. Biochem. Pharmacol. 26:1435–1439.

    PubMed  Google Scholar 

  10. Vickroy, W. T., andJohnson, K. M. 1980. In vivo administration of phencyclidine inhibits3H-dopamine accumulation by rat brain striatal slices. Subs. Alc. Act./Misuse 1:351–354.

    Google Scholar 

  11. Bagchi, S. P. 1981. Effect of phencyclidine on synaptosomal dopamine continuously appearing from phenylalanine: sensitivity to reserpine. Neuropharmacology 20:845–851.

    PubMed  Google Scholar 

  12. Beninger, R. J. 1983 The role of dopamine in locomotor activity and learning. Brain Res. Rev. 6:173–196.

    Google Scholar 

  13. Cherany, A., Nieoullon, A., andGlowinsky, J. 1978. Inhibition of dopamine release in the cat caudate nucleus by nigral application of glycine. Eur. J. Pharmacol. 47:141–147.

    PubMed  Google Scholar 

  14. Leviel, V., Cherany, A., Nieoullon, A., andGlowinsky, J. 1979. Symmetric bilateral changes in dopamine release from the caudate nuclei of the cat induced by unilateral nigral application of glycine and GABA-related compounds. Brain Res. 175:259–270.

    PubMed  Google Scholar 

  15. Toth, E., Lajtha, A., Sarhan, S., andSeiler, N. 1983. Anticonvulsant effects of some inhibitory neurotransmitter amino acids. Neurochem. Res. 8:291–301.

    Google Scholar 

  16. Toth, E. andLajtha, A. 1981. Elevation of cerebral levels of nonessential amino acids in vivo by administration of large doses. Neurochem. Res. 6:1309–1317.

    Google Scholar 

  17. Toth, E. andLajtha, A. 1980. Effect of protein-free diet on the uptake of amino acids by brain in vivo. Exp. Neurol. 68:443–452.

    PubMed  Google Scholar 

  18. Seversan, J. A., Randall, P. K., andFinch, C. E. 1981. Genotypic influences on striatal dopaminergic regulation in mice. Brain Res. 210:201–215.

    PubMed  Google Scholar 

  19. Boehue, E. R. andCiaranello, D. R. 1982. Genetic control of dopamine and serotonin receptors in brain regions of inbred mice. Brain Res. 266:51–65.

    Google Scholar 

  20. Toth, E. andLajtha, A. 1984. Brain protein synthesis rates are not sensitive to elevated GABA, taurine or glycine. Neurochem. Res. 9:173–179.

    PubMed  Google Scholar 

  21. Seiler, N., andSarhan, S. 1984. Synergistic anticonvulsant effects of GABA-T inhibitors and glycine. Naunyn-Schmiedeberg's Arch. Pharmacol. 311:179–184.

    Google Scholar 

  22. Pycock, C. J., andKerwin, R. W. 1981. The status of glycine as a supraspinal neurotransmitter. Life Sci. 28:2679–2686.

    PubMed  Google Scholar 

  23. McGeer, P. L., Eccles, J. C., andMcGeer, E. G. 1978. Molecular Neurobiology of the Mammalian Brain. Page 229, Plenum Press, New York.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Neurochemistry, The Nathan S. Kline Institute for Psychiatric Research, Ward's Island, 10035, New York, NY

    Eugene Toth & Abel Lajtha

Authors
  1. Eugene Toth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abel Lajtha
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Toth, E., Lajtha, A. Antagonism of phencyclidine-induced hyperactivity by glycine in mice. Neurochem Res 11, 393–400 (1986). https://doi.org/10.1007/BF00965013

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00965013

Keywords

Search

Navigation