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Cerebral myelinogenesis in theSnell dwarf mouse: Stimulatory effects of GH and T4 restricted to the first 20 days of postnatal life

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Abstract

We attempted to define the critical time period during early postnatal life when GH and T4 are essential for myelination. We administered bGH and T4 toSnell dwarf mice during the first and second 20 days after birth. Positive results were obtained only when hormones were given during the first 20 days of postnatal life. We observed a distinct increase in brain weight, DNA content, CNPase activity and a remarkably increased level of spontaneous locomotion activity with a diurnal periodicity. Morphological observations of brain sections stained for myelin basic protein (MBP) correlated the biochemical findings. The later administration of hormones was ineffective. Our interpretation is that the administration of exogenous hormones led to increased myelinogenesis through their stimulatory effects on glial proliferation, as evidenced by the increase in cerebral DNA content.

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Authors and Affiliations

  1. Department of Physiology Keio University School of Medicine, Ohmori-nishi, Tokyo 143, Japan

    Tetsuro Sugisaki & Yasuzo Tsukada

  2. Department of Physiology, Toho University School of Medicine, Ohmori-nishi, Tokyo 143, Japan

    Tetsuya Noguchi

Authors
  1. Tetsuro Sugisaki
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  2. Tetsuya Noguchi
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  3. Yasuzo Tsukada
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Sugisaki, T., Noguchi, T. & Tsukada, Y. Cerebral myelinogenesis in theSnell dwarf mouse: Stimulatory effects of GH and T4 restricted to the first 20 days of postnatal life. Neurochem Res 10, 767–778 (1985). https://doi.org/10.1007/BF00964534

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  • DOI: https://doi.org/10.1007/BF00964534

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