Abstract
Glutathione peroxidase and glutathione reductase activities were measured in whole rat brains at selected ages from birth to adulthood. On a wet weight basis glutathione peroxidase activity increased 70% during development and glutathione reductase activity increased 160%. On a protein basis glutathione peroxidase declined slightly in activity during the first two weeks of life and then maintained the 14-day activity into adulthood while glutathione reductase showed a 30% increase in activity. While less than the developmental changes in many enzymes involved in aerobic glycolysis or catecholamine metabolism, these increases do suggest a role in CNS metabolism.
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Brannan, T.S., Maker, H.S. & Weiss, C. Developmental study of rat brain glutathione peroxidase and glutathione reductase. Neurochem Res 6, 41–45 (1981). https://doi.org/10.1007/BF00963904
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DOI: https://doi.org/10.1007/BF00963904