Abstract
The literature contains studies on many causes of demyelination: Vascular occlusion —exogenous toxins—allergic reactions—and virus diseases. There remains, however, a small group of conditions which seems to have been ignored almost completely in discussions of cerebral demyelination. These consist of brain damage apparently resulting from some toxin liberated within the human body and not obtained from the outside.
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References
Baker, A. B. 1950. Demyelination resulting from endogenous toxins. Assoc. Res. Nerv. Ment. Dis. 28:59–74.
Dawson, J. W. 1916. The histology of disseminated sclerosis. Edinburgh Med. J. 17:377–410.
Hassin, G. B. 1922. Studies in the pathogenesis of multiple sclerosis. Arch. Neurol. Psychiatr. 7:589–607.
Globus, J. H., andStrauss, I. 1928. Progressive degenerative subcortical encephalopathy. Arch. Neurol. Psychiatr. 20:1190–1228.
Meyer, A., andTennent, T. 1936. Familial Schilder's disease. Brain 59:100–112.
Peters, G. 1968. Multiple sclerosis. Pages 821–843,in Minckler, J. (ed.), Pathology of the Nervous System, Vol. 1, McGraw-Hill, New York.
Lumsden, C. E. 1970. The neuropathology of multiple sclerosis. Pages 217–309,in Vinken, P., and Bruyn, G. W. (eds.), Handbook of Clinical Neurology, Vol. 9, North Holland Publ., Amsterdam.
Brownell, B., andHughes, J. T. 1962. The distribution of plaques in the cerebrum in multiple sclerosis. J. Neurol. Neurosurg. Psychiatr. 25:315–320.
Hopf, H. C. 1965. Leitgeschwindigkeit motorischer nerven bei der multiplen sklerose und unter dem einfluss hoher cortisonmedikation. Dtsch. Z. Nervenheilkd. 187:522–526.
Hassin, G. B. 1921. Pathological studies in the pathogenesis of multiple sclerosis. Assoc. Res. Nerv. Ment. Dis. 2:144–156.
Hasson, J., Terry, R. D., andZimmerman, H. M. 1958. Peripheral neuropathology in multiple sclerosis. Neurology 8:503–510.
Margulis, M. S. 1933. Uber die pathologische anatomie und pathogenese der multiplen sklerose. Dtsch. Z. Nervenheilkd. 131:125–143.
Schob, F. 1907. Ein beitrag zur pathologischen anatomie der multiplen skelerose. Monatsschr. Psychiatr. Neurol. 22:62–87.
Strahuber, A. 1903. Ueber degenerations-und proliferations vorgange bei multipler sklerose des nervensystems, nebst bemerkungen zur aetiologie und pathogenese der erkrankung. Beitr. Pathol. Anat. 33:409–480.
Pollock, M., Calder, C., andAllpress, S. 1977. Peripheral nerve abnormality in multiple sclerosis. Ann. Neurol. 2:41–48.
Andrews, J. M. 1972. The ultrastructural neuropathology of multiple sclerosis. Pages 23–49,in Wolfgram, F., Ellison, G. W., Stevens, J. G., and Andrews, J. M. (eds.), Multiple Sclerosis: Immunology, Virology and Ultrastructure. UCLA Forum in Medical Sciences No. 16, Academic Press, New York.
Lampert, P. W. 1965. Demyelination and remyelination in experimental allergic encephalomyelitis. J. Neuropathol. Exp. Neurol. 24:371–385.
Meyer, A. 1928. Experimentalle erfahrungen uber die kohlenoxydvergiftung des zentralnervensystems. Ztschr. Ges. Neurol. Psychiatr. 112:187–212.
Putnam, T. J., McKenna, J., andMorrison, L. R. 1931. Studies in multiple sclerosis. 1. The histogenesis of experimental sclerotic plaques and their relation to multiple sclerosis. JAMA 97:1591–1596.
Yant, W. P., Chornyak, J., Schrenck, H. H. Patty, F. A., andSayers, R. R. 1934. Studies in asphyxia. U.S. Treasury Dept., Public Health Bull. 211.
Ferraro, A. 1933. Experimental toxic encephalomyelopathy. Psychiatr. Q. 7:267–283.
Hurst, E. W. 1940. Experimental demyelination of the central nervous system. 1. The encephalopathy produced by potassium cyanide. Aust. J. Exp. Biol. Med. Sci. 18:201–223.
Hurst, E. W. 1942. Experimental demyelination of the central nervous system. 3. Poisoning with potassium cyanide, sodium azide, hydroxylamine, narcotics, carbon monoxide, etc. with some consideration of bilateral necrosis occurring in the basal nuclei. Aust. J. Exp. Biol. Med. Sci. 20:297–312.
Hurst, E. W. 1944. A review of some recent observations on demyelination. Brain 67:103–124.
Putnam, J. J. 1883. Lead poisoning simulating other diseases. J. Nerv. Ment. Dis. 10:466–469.
Verhaart, W. J. C. 1941. Lead encephalopathy simulating diffuse sclerosis in a Chinese infant. Am. J. Dis. Child. 61:1246–1250.
Sauer, R. M., Zook, B. C., andGarner, F. M. 1970. Demyelinating encephalomyelopathy associated with lead poisoning in nonhuman primates. Science 169:1091–1093.
Smith, M. E. 1973. Studies on the mechanism of demyelination: Triethyl tin-induced demyelination. J. Neurochem. 21:357–372.
Baker, A. B., andTichy, F. Y. 1953. The effect of the organic solvents and industrial poisonings on the central nervous system. Assoc. Res. Nerv. Ment. Dis. 32:475–505.
Korenke, H. D., andPribilla, O. 1969. Suicid durch einmalige inhalation von tetrachlorkohlenstoff (CCl4) mit leukoencephalopathie. Arch. Toxikol. 25:109–126.
Weil, A. 1930. The effect of hemolytic toxins on nervous tissue. Arch. Pathol. 9:828–842.
Gonsette, R., Andre-Balisaux, G., andDelmotte, P. 1966. Permeability of the cerebral vessels. VI. Experimental demyelination provoked by substances acting on the blood-brain barrier. Acta Neurol. Belg. 66:247–262.
Davis, L., Haven, H., Givens, J. H., andEmmett, J. 1931. Effects of spinal anesthetics on the spinal cord and its membranes. JAMA 97:1781–1785.
Friedman, E. D. 1953. Neurologic sequelae of spinal anesthesia. N. Y. State J. Med. 53:1864–1866.
Poser, C. M. 1973. Demyelination in the central nervous system in chronic alcoholism: Central pontine myelinolysis and Marchiafava-Bignami's disease. Ann. N.Y. Acad. Sci. 215:373–381.
Marchiafava, E., andBignami, A. 1903. Sopra un'alterazione del corpo calloso osservata in soggetti alcoclisti. Riv. Patol. Nerv. Ment. 8:544–549.
Ironside, R., Bosanquet, F. D., andMcMenemey, W. H. 1961. Central demyelination of the corpus collosum (Marchiafava-Bignami disease). Brain 84:212–230.
Lynch, M. J. G. 1960. Brain lesions in chronic alcoholism. Arch. Pathol. 69:342–353.
Adams, R. D., Victor, M., andMancall, E. L. 1959. Central pontine myelinolysis. Arch Neurol. Psychiatr. 81:154–172.
Klavins, J. V. 1963. Central pontine myelinolysis. J. Neuropathol. Exp. Neurol. 22:302–317.
Sherins, R. J., andVerity, M. A. 1968. Central pontine myelinolysis associated with acute haemorrhagic pancreatitis. J. Neurol. Neurosurg. Psychiatr. 31:583–588.
Chason, J. L., Landers, J. W., andGonzalez, J. E. 1964. Central myelinolysis. J. Neurol. Neurosurg. Psychiatr. 27:317–325.
Waechter, R. V., andHoldorff, B. 1973. Akute zentrale pontine myelinolyse mit multifokaler ausbreitung. Z. Neurol. 204:193–208.
Balo, J. 1928. Encephalitis periaxialis concentrica. Arch. Neurol. Psychiatr. 19:242–264.
Hallervorden, J., andSpatz, H. 1933. Uber die konzentrische sklerose und die physikalischchemischen faktoren bei der ausbreitung von entmarkungsprozessen. Arch. Psychiatr. 98:641–701.
Davison, C., andKeschner, M. 1933. Myelitic and myelopathic lesions (A clinicopathologic study). Arch. Neurol. Psychiatr. 29:600–614.
Alvord, E. C., Stevenson, L. D., Vogel, F. S., andEngle, R. L. 1950. Neuropathological findings in phenylpyruvic oligophrenia (phenylketonuia). J. Neuropath. Exp. Neurol. 9:298–310.
Forssman, H., Kristensson, K., Sourander, P., andSvennerholm, L. 1967. Histological and chemical studies of a case of phenylketonuria with long survival. J. Ment. Def. Res. 11:194–206.
Malamud, N. 1966. Neuropathology of phenylketonuria. J. Neuropathol. Exp. Neurol. 25:254–268.
Gatfield, P. D., Taller, E., Hinton, G. G., Wallace, A. C., Abdelnour, G. M., andHaust, M. D. 1968. Hyperpipecolatemia: A new metabolic disorder associated with neuropathy and hepatomegaly: A case study. Can. Med. Assoc. J. 99:1215–1233.
Globus, J. H., andBender, M. B. 1936. Disseminated toxic degenerative encephalopathy (disseminated sclerosing demyelination) secondary to extensive and severe burns. J. Nerv. Ment. Dis. 83:518–529.
Solcher, H. 1971. Striare initiale entmarkungsherde nach verbrennung mit langerer uberlebungszeit. Acta Neuropathol. (Berlin) 19:75–78.
Knutson, J., andBaker, A. B. 1945. The central nervous system in uremia. Arch. Neurol. Psychiatr. 54:130–140.
Tichy, F. Y. 1950. Uremia encephalitis. J. Neuropathol. Exp. Neurol. 9:344–346.
Olsen, S. 1961. The brain in uremia. Acta Psychiatr. Neurol. Scand. 36(Suppl. 156):1–126.
Tyler, H. R. 1968. Neurologic disorders in renal failure. Am. J. Med. 44:734–748.
Giovannetti, S., andBarsotti, G. 1975. Uremic intoxication. Nephron 14:123–133.
Cohen, B. D. 1969. Guanidine retention and the urea cycle. Page 45,in 4th Int. Cong. Nephrology, Stockholm, June 22–27, Vol. 2, Karger, Basel.
Merrill, J. P., and Hampers, C. L. 1970. Uremia. N. Engl. J. Med. 282:953–961.
Adams, R. D., andFoley, J. M. 1953. The neurological disorder associated with liver disease. Assoc. Res. Nerv. Ment. Dis. 32:198–237.
Brown, I. A. 1957. Liver Brain Relationships, pp. 1–198, Charles C. Thomas, Springfield, Illinois.
Zieve, L., Mendelson, D. F., andGoepfert, M. 1960. Shunt encephalomyelopathy. II. Occurrence of permanent myelopathy. Ann. Intern. Med. 53:53–63.
Bechar, M., Freud, M., Kott, E., Kott, I., Kravvic H., Stern, J., Sandbank, U., andBornstein, B. 1970. Hepatic cirrhosis with post-shunt myelopathy. J. Neurol. Sci. 11:101–107.
Baltzan, M. A., Olszewski, J., andZervas, N. 1957. Chronic portohepatic encephalopathy. J. Neuropathol. Exp. Neurol. 16:410–421.
Liversedge, L. A., andRawson, M. D. 1966. Myelopathy in hepatic disease and portosystemic venous anastomosis. Lancet 1:277–279.
Marquardt, P., andWerringloer, H. W. J. 1965. Toxicity of wine. Food Cosmet. Toxicol. 3:803–810.
Balo, J., andKopassy, B. 1932. The encephalitis of dogs with Eck fistula fed on meat. Arch. Pathol. 13:80–87.
Riddell, A. G., Kopple, P. N., andMcDermott, W. V., Jr 1954. The etiology of meat intoxication in the Eck fistula dog. Surgery 36:675–684.
Alter, M., Leibowitz, U., andSpeer, J.. 1966. Risk of multiple sclerosis related to age at immigration to Israel. Arch. Neurol. 15:234–237.
Alter, M., andOkihiro, M. 1971. When is multiple sclerosis acquired? Neurology 21:1030–1036.
Ikuta, F., andZimmerman, H. M.. 1976. Distribution of plaques in 70 autopsy cases of multiple sclerosis in the United States Neurology 26 (pt. 2):26–28.
Monseu, G., andFlament-Durand, J. 1971 Pathogenesis of central pontine myelinolysis. A clinical and pathological description of three cases. Pathol. Eur. 6:75–94.
Aleu, F. P., andTerry, R. D. 1963. Central pontine myelinolysis. A report of two cases. Arch. Pathol. 76:140–146.
Burkitt, D. P. 1971. The aetiology of appendicitis. Br. J. Surg. 58:695–699.
Burkitt, D. P. 1971. Epidemiology of cancer of the colon and rectum. Cancer 28:3–13.
Putnam, T. J. 1938. The centenary of multiple sclerosis. Arch. Neurol. Psychiatr. 40:806–813.
Firth, D. 1948. The Case of Auguste D'Este. University Press, Cambridge, England.
New York Neurological Society, 1902. Multiple Sclerosis. J. Nerv. Ment. Dis. 29:288–290.
Maretschek, M., Schaltenbrand, G., andSeibert, P. 1954. Statische untersuchungen uber die multiple skelerose an hand von 947 sektionsprotokollen. Dtsch. Z. Nervenheilkd. 172:287–308.
Poskanzer, D., Walker, A. M., Yonkondy, J., andSheridan, J. L. 1976. Studies in the epidemiology of multiple sclerosis in the Orkney and Shetland Islands. Neurology 26 (pt. 2):14–17.
Leibowitz, U. 1971. Multiple sclerosis: Progress in epidemiologic and experimental research. J. Neurol. Sci. 12:307–318.
Dean, G. 1967. Annual incidence, prevalence and mortality of multiple sclerosis in white South-African born and in white immigrants to South Africa. Br. Med. J. 2:724–730.
Foster, R. M., andHarries, J. R. 1970. Multiple sclerosis in the African. Br. Med. J. 3:628.
Oh, S. J., andCalhoun, C. L. 1969. Multiple sclerosis in the Negro. J. Natl. Med. Assoc. 61:388–392.
Kurtzke, J. F., Kurland, L. T., andGoldberg, I. D. 1971. Mortality and migration in multiple sclerosis. Neurology 21:1186–1197.
Burbank, F. 1971 Patterns in cancer mortality in the United States: 1950–1967. Natl. Cancer Inst. Monag No. 33, National Institutes of Health, Bethesda, Maryland.
United States Department of Health, Education and Welfare 1963. Public Health Services. Cardiovascular Disease: 1960, Data on national and state mortality experience. Washington, D.C., Govt. Printing Office, PHS Publication No. 1083.
Strøm, A., andJensen, R.A. 1951. Mortality from circulatory disease in Norway 1940–1945. Lancet 1:126–129.
Swank, R. L. 1950. Multiple sclerosis: A correlation of its incidence with dietary fat. Am. J. Med. Sci. 220:421–430.
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Wolfgram, F. What if multiple sclerosis isn't an immunological or a viral disease? the case for a circulating toxin. Neurochem Res 4, 1–14 (1979). https://doi.org/10.1007/BF00963827
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DOI: https://doi.org/10.1007/BF00963827