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The effect of neuronal growth on synaptic integration

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Abstract

The way in which the dimensions of neurons change during postembryonic development has important effects on their electrotonic structures. Theoretically, only one mode of growth can conserve the electrotonic structures of growing neurons without employing changes in membrane electrical properties. If the dendritic diameters of a neuron increase as the square of the increase in dendritic lengths, then the neuron's electrotonic structure is conserved. We call this special mode of allometric growth “isoelectrotonic growth.” In this study we compared the developmental changes in morphology of two identified invertebrate neurons with theoretical growth curves. We found that a cricket neuron, MGI, grows isoelectrotonically and thereby preserves its electrotonic properties. In contrast, the crayfish neuron, LG, grows in a nearly isometric manner resulting in an increase in its electrotonic length.

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Authors and Affiliations

  1. Neuroscience and Behavior Program, Department of Biology, Morrill Science Center South, University of Massachusetts at Amherst, 01003-35825, MA

    Andrew A. V. Hill & Rodney K. Murphey

  2. Department of Biology, Georgia State University, 30302-4010, Atlanta, GA

    Donald H. Edwards

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  1. Andrew A. V. Hill
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  2. Donald H. Edwards
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  3. Rodney K. Murphey
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Correspondence to Andrew A. V. Hill.

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Hill, A.A.V., Edwards, D.H. & Murphey, R.K. The effect of neuronal growth on synaptic integration. J Comput Neurosci 1, 239–254 (1994). https://doi.org/10.1007/BF00961736

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  • DOI: https://doi.org/10.1007/BF00961736

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