Abstract
The ability of technetium 99m labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in patients with rheumatoid arthritis (RA). Eight patients with clinically active synovitis were injected with 350 MBq99mTc-IgG, and imaging took place 4 h later. This resulted in excellent images of inflamed synovium. Significant correlations were observed between individual joint uptake on the scan and scores for joint pain (n=316,p<0.001), joint swelling (n = 300,p < 0.001) or the average of pain and swelling (n = 300,p < 0.001). These results suggest that99mTc-IgG scintigraphy may provide an objective, non-invasive test to detect and measure synovitis.
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References
Blok D, van Ogtrop M, Arndt JW, Camps JAJ, Feitsma RIJ, Goedemans W, Pauwels EKJ (1990) Detection of inflammatory lesions with radiolabelled immunoglobulins. Eur J Nucl Med 16:303–305
Breedveld FC, van Kroonenburgh MJPG, Camps JAJ, Feitsma HIJ, Markusse HM, Pauwels EKJ (1989) Imaging of inflammatory arthritis with technetium-99m labeled IgG. J Nucl Med 30:2017–2021
Buscombe JR, Lui D, Ensing G, de Jong R, Ell PJ (1990) Tc-99m-human immunoglobulin (HIG) — first results of a new agent for the localization of infection and inflammation. Eur J Nucl Med 16:649–655
Fischman AJ, Rubin RH, Khaw BA, Callahan RJ, Wilkinson R, Keech F, Nedelman M, Dragotakes S, Kramer PB, LaMuraglia GM, Lind S, Strauss HW (1988) Detection of acute inflammation with In-111 labelled nonspecific polyclonal IgG. Semin Nucl Med 18:335–344
Fischman AJ, Rubin RH, White JA, Locke E, Wilkinson RA, Nedelman M, Callahan RJ, Khaw BA, Strauss HW (1990) Localization of Fe and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation. J Nucl Med 31:1199–1205
Morrel EM, Tompkins RG, Fischman AJ, Wilkinson RA, Burke JF, Rubin RH, Strauss HW, Yarmush ML (1989) Autoradiographic method for quantitation of radiolabeled proteins in tissues using indium-111. J Nucl Med 30:1538–1545
Oyen WJG, Claessens RAMJ, van Horn JR, van der Meer JWM, Corstens FHM (1990) Scintigraphic detection of bone and joint infections with indium-111-labeled nonspecific polyclonal human immunoglobulin G. J Nucl Med 31:403–412
Rubin RH, Young LS, Hansen WP, Nedelman M, Wilkinson R, Nelles MJ, Callahan RJ, Khaw BA, Strauss HW (1988) Specific and non-specific imaging of localized Fisher immunotype 1Pseudomonas aeruginosa infection with radiolabeled monoclonal antibody. J Nucl Med 29:651–656
Rubin RH, Fischman AJ, Nedelman M, Wilkinson R, Callahan RJ, Khaw BA, Hansen WP, Kramer PB, Strauss HW (1989) Radiolabeled, nonspecific, polyclonal human immunoglobulin in the detection of focal inflammation by scintigraphy: comparison with gallium-67 citrate and technetium-99m labeled albumin. J Nucl Med 30:385–389
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van der Lubbe, P.A.H.M., Arndt, J.W., Calame, W. et al. Measurement of synovial inflammation in rheumatoid arthritis with technetium 99m labelled human polyclonal immunoglobulin G. Eur J Nucl Med 18, 119–123 (1991). https://doi.org/10.1007/BF00950757
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DOI: https://doi.org/10.1007/BF00950757