Skip to main content
SpringerLink
Log in

Repair of demyelinated lesions by glial cell transplantation

  • Published:
Journal of Neurology Aims and scope Submit manuscript

Abstract

Transplantation of oligodendrocyte lineage cells results in myelination of naked axons. The most extensive remyelination is achieved using A2B5 positive progenitor cells and these observations encourage the view that glial transplantation may be a useful treatment in human demyelinating diseases. However, several issues need to be resolved before glial cell transplantation can be applied clinically; this review focuses on the choice of cells, their source, whether chronically demyelinated axons can be repaired by transplantation, and whether the principles of glial transplantation established in small rodents are applicable to other mammalian species and to man.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Barnett SC, Franklin RJM, Blakemore WF (1993) In vitro and in vivo analysis of a rat bipotential O-2A progenitor cell line containing the temperature sensitive mutant gene of the SV 40 large T antigen. Eur J Neurosci 5: 1247–1260

    Google Scholar 

  2. Blakemore WF, Franklin RIM (1991) Transplantation of glial cells into the CNS. Trends Neurosci 14: 323–327

    Google Scholar 

  3. Blakemore WF (1992) Transplanted cultured type-1 astrocytes can be used to re-contruct the glia limitans of the CNS: the structure which prevents Schwann cells from myelinating CNS axons. Neuropathol Appl Neurobiol 18: 460–466

    Google Scholar 

  4. Blakemore WF, Crang AJ (1989) The relationship between type-1 astrocytes, Schwann cells and oligodendrocytes following transplanation of glial cell cultures into demyelinating lesions in the adult rat spinal cord. J Neurocytol 18: 519–528

    Google Scholar 

  5. Blakemore WF, Crang AJ (1993) A multidisciplinary approach to myelin diseases. Edited by S Salvatini. New York: Nato A.S.I. Series, Plenum Press pp. 185–194

    Google Scholar 

  6. Duncan ID, Hammang JP, Jackson KF, Wood PM, Bunge RP, Langford L (1988) Transplantation of oligodendrocytes, and Schwann cells into the spinal cord of the myelin deficent rat. J Neurocytol 17: 351–360

    Google Scholar 

  7. Duncan ID, Paino C, Archer DR, Wood PM (1992) Functional capacities of transplanted cell-sorted adult oligodendrocytes. Devel Neurosci 14: 114–122

    Google Scholar 

  8. ffrench-Constant C, Raff MC (1986) Proliferating bipotential glial progenitor cells in adult optic nerve. Nature 319: 499–502

    Google Scholar 

  9. Franklin RIM, Crang AJ, Blakemore WF (1991) Transplanted type-1 astrocytes facilitate repair of demyelinating lesions by host oligodendrocytes in adult rat spinal cord. J Neurocytol 20: 420–430

    Google Scholar 

  10. Franklin RIM, Crang AJ, Blakemore WF (1993) The reconstruction of an astrocytic environment in glia-deficient areas of white matter. J Neurocytol 22: 382–396

    Google Scholar 

  11. Groves AK, Barnett SC, Franklin RIM, Crang AJ, Mayer M, Blakemore WF, Noble M (1993) Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells. Nature 362: 453–455

    Google Scholar 

  12. Gumpel M, Baumann N, Raoul M, Jacque C (1983) Survival and differentiation of oligodendrocytes from neural tissue transplanted into new-born mouse brain. Neurosci Lett 37: 307–311

    Google Scholar 

  13. Targett MP, Blakemore WF (1994) The use of xenografting to evaluate the remyelinating potenial of glial cell cultures. Eye 8: 238–244

    Google Scholar 

  14. Trotter J, Crang AJ, Schachner M, Blakemore WF (1993) Lines of glial precursor cells immortalised with a temperature-sensitive oncogene give rise to astrocytes and myelin-forming oligodendrocytes on transplanation into demyelinated lesions in the central nervous system. Glia 9: 25–40

    Google Scholar 

  15. Warrington AE, Barbarese E, Pfeiffer SE (1993) Differential myelinogenic capacity of specific developmental stages of the oligodendrocyte lineage upon transplantation into hypomyelinating hosts. J Neurosci Res 34: 1–13

    Google Scholar 

  16. Wolswijk G, Noble M (1992) Cooperation Between PDGF and FGF converts slowly dividing O-2A (adult) Progenitor cells to rapidly dividing cells with characteristics of O-2A (perinatal) progenitor cells. J Cell Biol 118: 889–900

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cambridge Centre for Brain Repair and Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, CB3 OES, Cambridge, UK

    W. F. Blakemore, R. J. M. Franklin & A. J. Crang

Authors
  1. W. F. Blakemore
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. J. M. Franklin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. J. Crang
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Blakemore, W.F., Franklin, R.J.M. & Crang, A.J. Repair of demyelinated lesions by glial cell transplantation. J Neurol 242 (Suppl 1), S61–S63 (1994). https://doi.org/10.1007/BF00939245

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00939245

Keywords

Search

Navigation