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Endocrine strategies for the control of ectoparasites and insect pests

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Abstract

The increasing knowledge about endocrine mechanisms in arthropods facilitates the biorational search for drugs against insect pests and parasites that interfere with arthropod hormone action. Juvenile hormone mimics have been successfully applied for about 20 years; however, resistance to juvenile hormone analogues has developed. The introduction of moulting hormone agonists, which compete for binding to the ecdysteroid receptor, is expected in the near future. Despite the considerable progress that has been achieved in peptide hormone research during the last few years, no successful insecticide is currently available, although comparisons of drugs for medical use demonstrate that in principle, successful interference with peptide hormone action is possible. The search for new drugs has been facilitated by advances in cell-culture techniques, which improve the development of suitable screening systems, and by progress in genetic engineering, which could be an important tool in the creation of new strategies for insect pest control.

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References

  • Barker GC, Chitwood DJ, Rees HH (1990) Ecdysteroids in helminths and annelids. Invertebr Reprod Dev 18:1–11

    Google Scholar 

  • Barton AE, Wing KD, Le DP, Slawecki RA, Feyereisen R (1989) Arylpyridyl-thiosemicarbazones: a new class of anti-juvenile hormones active against Lepidoptera. Experientia 45:580–583

    Google Scholar 

  • Beato M (1991) Transcriptional control by nuclear receptors. FASEB J 7:2044–2051

    Google Scholar 

  • Bergamasco R, Horn DHS (1980) The biological activities of ecdysteroids and ecdysteroid analogues. In: Hoffmann JA (ed) Progress in ecdysone research. Elsevier/North-Holland, Amsterdam, pp 299–324

    Google Scholar 

  • Bidmon HJ, Sliter TJ (1990) The ecdysteroid receptor. Invertebr Reprod Dev 18:13–27

    Google Scholar 

  • Casida JE (1990) Pesticides and alternatives: innovative chemical and biological approaches to pest control. Elsevier, Amsterdam, p 586

    Google Scholar 

  • Cherbas L, Yonge CP, Cherbas P, Williams CM (1980) The morphological response of Kc−H cells to ecdysteroids: hormonal specificity. Wilhelm Roux's Arch Entwicklungsmech Org 189:1–15

    Google Scholar 

  • Cusson M, Yagi KJ, Ding Q, Duve H, Thorpe A, McNeil JN, Tobe SS (1991) Biosynthesis and release of juvenile hormone and its precursors in insects and crustaceans: the search for a unifying arthropod endocrinology. Insect Biochem 21:1–6

    Google Scholar 

  • De Loof A (1987) The impact of the discovery of vertebrate-type steroids and peptide hormone-like substances in insects. Entomol Exp Appl 45:105–113

    Google Scholar 

  • De Loof A, Schoofs L (1990) Homologies between the amino acid sequences of some vertebrate peptide hormones and peptides isolated from invertebrate sources. Comp Biochem Physiol [B] 95:459–468

    Google Scholar 

  • De Loof A, Schoofs L, Broeck JV (1990) Molecular structures of some vertebrate-tpe messenger peptides in invertebrates. In: Epple A, Scannes CG, Stetson MH (eds) Progress in comparative endocrinology. Wiley-Liss, New York, pp 16–21

    Google Scholar 

  • Dinan L (1989) Ecdysteroid structure and hormonal activity. In: Koolman J (ed) Ecdysone. From chemistry to mode of action. Georg Thieme, Stuttgart, pp 345–353

    Google Scholar 

  • Dinan L, Spindler-Barth M, Spindler KD (1990) Insect cell lines as tools for studying ecdysteroid action. Invertebr Reprod Dev 18:43–53

    Google Scholar 

  • Dübendorfer A (1989) Ecdysteroid action in embryonic systems. In: Koolman J (ed) Ecdysone. From chemistry to mode of action. Georg Thieme, Stuttgart, pp 421–425

    Google Scholar 

  • Evans BE, Bock MG, Rittle KE, DiPardo RM, Whitter WL, Veber DF, Anderson PS, Freidinger RM (1986) Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin. Proc Natl Acad Sci USA 83:4918–4922

    Google Scholar 

  • Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889–895

    Google Scholar 

  • Ferenz HJ, Peter MG (1987) The inhibitory effect of sinefungin on juvenile hormone biosynthesis and development in locusts. Insect Biochem 17:1119–1122

    Google Scholar 

  • Franke K, Käuser G (1989) Occurrence and hormonal role of ecdysteroids in non-arthropods. In: Koolman J (ed) Ecdysone. From chemistry to mode of action. Georg Thieme, Stuttgart, pp 296–307

    Google Scholar 

  • Gadenne C, Varjas L, Mauchamp B (1990) Effects of the non-steroidal ecdysone mimic, RH-5849, on diapause and non-diapause larvae of the European corn borer,Ostrinia nubilalis Hbn. J Insect Physiol 36:555–559

    Google Scholar 

  • Garcia ES, Luz N, Azambuja P, Rembold H (1990) Azadirachtin depresses the release of prothoracicotropic hormone inRhodnius prolixus larvae: evidence from head transplantations. J Insect Physiol 36:679–682

    Google Scholar 

  • Goldsworthy GJ, Wheeler CH, Cusinato O, Wilmot CM (1990) Adipokinetic hormones: structures and functions. In: Epple A, Scannes CG, Stetson MH (eds) Progress in comparative endocrinology, vol 342. Wiley-Liss, New York, pp 28–34

    Google Scholar 

  • Hammock BD, Abdel-Aal YAI, Mullin CA, Hanzlik TN, Roe RM (1984) Substituted thiotrifluoropropanones as potent selective inhibitors of juvenile hormone esterase. Pest Biochem Physiol 22:209–223

    Google Scholar 

  • Hammock BD, Bonning BC, Possee RD, Hanzlik TN, Maeda S (1990) Expression and effects of the juvenile hormone esterase in a baculovirus vector. Nature 344:458–461

    Google Scholar 

  • Harrow ID, Gration KAF, Evans NA (1991) Neurobiology of arthropod parasites. Parasitology 102:S59-S69

    Google Scholar 

  • Hetru C, Roussel JP, Mori K, Nakatani Y (1986) Activité antiecdystéroide de brassinostéroides. C R Acad Sci [II] 302:417–420

    Google Scholar 

  • Holman GM, Nachman RJ, Wright MS (1990) Comparative aspects of insect myotropic peptides. In: Epple A, Scannes CG, Stetson MH (eds) Progress in comparative endocrinology, vol 342. Wiley-Liss, New York, pp 35–39

    Google Scholar 

  • Hutson DH, Roberts TR (eds) (1985) Insecticides, vol 5. John Wiley & Sons, Chichester, p 385

    Google Scholar 

  • Ilenchuk TT, Davey KG (1985) The binding of juvenile hormone to membranes of follicle cells in the insectRhodnius prolixus. Can J Biochem Cell Biol 63:102–106

    Google Scholar 

  • Ilenchuk TT, Davey KG (1987) Effects of various compounds on Na/K-ATPase activity, JH I binding capacity and patency response in follicles ofRhodnius prolixus. Insect Biochem 17:1085–1088

    Google Scholar 

  • Keller R (1990) Neurosekretion und Neuropeptide im Nervensystem von dekapoden Crustaceen. Verh Dtsch Zool Ges 83:313–327

    Google Scholar 

  • Kelly TJ, Masler EP, Menn JJ (1990) Insect neuropeptides: new strategies for insect control. In: Casida JE (ed) Pesticides and alternatives: innovative chemical and biological approaches to pest control. Elsevier, Amsterdam, pp 283–297

    Google Scholar 

  • Kerkut GA, Gilbert LI (eds) (1985) Comprel onsive insect physiology, biochemistry and pharmacology, vol 12. Insect control. Pergamon Press, Oxford, p 849

    Google Scholar 

  • Koolman J, Spindler KD (1983) Mechanism of action of ecdysteroids. In: Downer HRGH, Laufer H (eds) Endocrinology of insects. A. Liss, New York, pp 179–201

    Google Scholar 

  • Koolman J, Bidmon HJ, Lehmann M, Käuser G (1988) On the mode of action of azadirachtin in blowfly larvae and pupae. In: Sehnal F, Zabza A, Denlinger DL (eds) Endocrinological Frontiers in Physiological Insect Ecology. Wrodrov. Technical University Press, Wodrov, pp 55–67

    Google Scholar 

  • Lafont R, Connat JL (1989) Pathways of ecdysone metabolism. In: Koolman J (ed) Ecdysone. From chemistry to mode of action. Georg Thieme, Stuttgart, pp 167–173

    Google Scholar 

  • Lafont R, Horn DHS (1989) Phytoecdysteroids: structure and occurrence. In: Koolman J (ed) Ecdysone. From chemistry to mode of action. Georg Thieme, Stuttgart, pp 39–64

    Google Scholar 

  • Lehmann M, Vorbrodt HM, Adam G, Koolman J (1988) Antiecdysteroid activity of brassinosteroids. Experientia 44:355–356

    Google Scholar 

  • Loudershausen M, Spindler-Barth M, Spindler KD (1989) Influence of the insect growth regulator SIR 8514 on chitin synthesis, chitin degradation and ecdysteroid titer. In: Skjak-Baerk G, Anthonson T, Sandford P (eds) Chitin and chitosan, Elsevier Applied Science, London, pp 233–242

    Google Scholar 

  • Luo Y, Amin J, Voellmy R (1991) Ecdysterone receptor is a sequence-specific transcription factor involved in the developmental regulation of heat shock genes. Mol Cell Biol 11:3660–3675

    Google Scholar 

  • Mehlhorn H (ed) (1988) Parasitology in focus. Facts and trends. Springer, Berlin, p 924

    Google Scholar 

  • Mehlhorn H, Spindler KD, Spindler-Barth M, Walldorf V, Andrews P, Thomas H (1986) The effect of precocene II and 20-OH-ecdysone onLitosomoides carinii andDipetalonema viteae in vivo. Z Parasitenkd 72:843–845

    Google Scholar 

  • Nachman RJ, Roberts VA, Holman GM, Trainer JA (1990) Consensus chemistry and conformation of an insect neuropeptide family analogous to tachykinins. In: Epple A, Scannes CG, Stetson MH (eds) Progress in comparative endocrinology, vol 342. Wiley-Liss, New York, pp 60–66

    Google Scholar 

  • Oberlander H, Miller S (1987) Lepidopteran cell lines: tools for research in physiology, development, and genetics. In: Maramorosch K (ed) Advances in cell culture, vol 5. Academic Press, New York, pp 187–207

    Google Scholar 

  • Ondetti MA, Rubin B, Cushman DW (1977) Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science 196:441–444

    Google Scholar 

  • Ohnishi E, Ishizaki H (1990) (eds) Molting and metamorphosis. Japan Scientific Societies Press, Tokyo, p 270

    Google Scholar 

  • O'Reilley DR, Miller LK (1989) A baculovirus blocks insect molting by producing ecdysteroid UDP-glycosyl transferase. Science 245:1110–1112

    Google Scholar 

  • O'Shea M (1991) Introduction to neuropeptides: perspectives for the parasitologist. Parasitology 102:S71-S75

    Google Scholar 

  • Palli RS, Riddiford LM, Hiruma K (1991) Juvenile hormone and “retinoic acid” receptors inManduca epidermis. Insect Biochem 21:7–15

    Google Scholar 

  • Retnakaran A, Granett J, Ennis T (1985) Insect growth regulators. In: Kerkut GA, Gilbert LI (eds) Comprehensive insect physiology, biochemistry and pharmacology, vol 12. Pergamon Press, Oxford, pp 529–601

    Google Scholar 

  • Riddiford LM, Ashburner M (1991) Effects of juvenile hormone mimics on larval development and metamorphosis ofDrosophila melanogaster. Gen Comp Endocrinol 2:172–183

    Google Scholar 

  • Roques BP, Fournié-Zaluski MC, Soroca E, Lecomte JM, Malfroy B, Llorens C, Schwartz JC (1980) The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice. Nature 288:286–288

    Google Scholar 

  • Schmutterer H (1988) Potential of azadirachtin-containing pesticides for integrated pest control in developing and industrialized countries. J Insect Physiol 34:713–719

    Google Scholar 

  • Seagraves WA, Hogness DS (1990) The E75 ecdysone-inducible gene responsible for the 95B early puff inDrosophila encodes two new members of the steroid receptor superfamily. Genes Dev 4:204–219

    Google Scholar 

  • Shaaya E, Spindler KD (1990) The effect of methoprene on RNA and chitinolytic enzyme synthesis and on ecdysteroid titer in some insects. In: Casida JE (ed) Pesticides and alternatives: innovative chemical and biological approaches to pest control. Elsevier, Amsterdam, pp 271–282

    Google Scholar 

  • Shaaya E, Calderon M, Pisarev V, Spindler KD (1991) The effect of juvenile hormone on life span, egg production and ecdysteroid titer inEphestia cautella females. Arch Insect Biochem Physiol (in press)

  • Shaw C, Johnston CF (1991) Role of regulatory peptides in parasitic platyhelminths and their vertebrate hosts: possible novel factors in host-parasite interactions. Parasitology 102:S93-S105

    Google Scholar 

  • Shemshedini L, Wilson TG (1990) Resistance to juvenile hormone and an insect growth regulator inDrosophila is associated with an altered cytosolic juvenile hormone-binding protein. Proc Natl Acad Sci USA 87:2072–2076

    Google Scholar 

  • Silhacek DL, Oberlander H, Porcheron P (1990) Action of RH 5849, a non-steroidal ecdysteroid mimic, onPlodia interpunctella (Huebner) in vivo and in vitro. Arch Insect Biochem Physiol 15:201–212

    Google Scholar 

  • Smith W, Sedlmeier D (1990) Neurohormonal control of ecdysone production: comparison of insects and crustaceans. Invertebr Reprod Dev 18:77–89

    Google Scholar 

  • Soltani N, Delbeque JP, Delachambre J, Mauchamp B (1984) Inhibition of ecdysteroid increase by diflubenzuron inTenebrio molitor pupae and compensation of diflubenzuron effect on cuticle secretion by 20-hydroxyecdysone. Int J Invertebr Reprod Dev 7:323–332

    Google Scholar 

  • Spindler KD (1988) Parasites and hormones. In: Mehlhorn H (ed) Parasitology in focus. Facts and trends. Springer, Berlin, pp 465–476

    Google Scholar 

  • Spindler KD, Spindler-Barth M (1989) Uptake of ecdysteroids. In: Koolman J (ed) Ecdysone. From chemistry to mode of action. Georg Thieme, Stuttgart, pp 245–249

    Google Scholar 

  • Spindler KD, Spindler-Barth M (1991) Ecdysteroid production and metabolism by an epithelial cell line fromChironomus tentans. Naturwissenschaften 78:78–79

    Google Scholar 

  • Spindler KD, Spindler-Barth M, Mehlhorn H (1986) Effects of the juvenile hormone antagonist precocene II and the moulting hormone 20-OH-ecdysone onLitosomoides carinii andDipetalonema viteae in vitro. Z Parasitenkd 72:837–841

    Google Scholar 

  • Spindler KD, Spindler-Barth M, Londershausen M (1990) Chitin metabolism: a target for drugs against parasites. Parasitol Res 76:283–288

    Google Scholar 

  • Spindler-Barth M (1991) Hormonal regulation of acetylcholinesterase in an epithelial cell line fromChironomus tentans Z Name forsch (in press)

  • Spindler-Barth M, Spindler KD (1987) Antieedysteroids and receptors. In: Agarwal MK (ed) Receptor mediated antisteroid action. Walter de Gruyter, Berlin, pp 497–511

    Google Scholar 

  • Spindler-Barth M, Schmidt H, Drews U, Spindler KD (1988) Increase in activity of acetylcholinesterase by 20-OH-ecdysone in aChironomus tentans cell line. Roux's Arch Dev Biol 197:366–369

    Google Scholar 

  • Spindler-Barth M, Turberg A, Spindler KD (1991) On the action of RH 5849, a nonsteroidal ecdysteroid agonist, on a cell line fromChironomus tentans. Arch Insect Biochem Physiol 16:11–18

    Google Scholar 

  • Spring JH (1990) Endocrine regulation of diuresis in insects. J Insect Physiol 36:13–22

    Google Scholar 

  • Watson RD, Spaziani E, Bollenbacher WE (1989) Regulation of ecdysone biosynthesis in insects and crustaceans: a comparison. In: Koolman J (ed) Ecdysone. From chemistry to mode of action. Georg Thieme, Stuttgart, pp 188–203

    Google Scholar 

  • Williams CM (1967) Third generation pesticides. Sci Am 217:13–17

    Google Scholar 

  • Wing KD (1988) RH 5849, a nonsteroidal ecdysone agonist: effects on aDrosophila cell line. Science 241:467–469

    Google Scholar 

  • Wing KD, Aller HE (1990) Ecdysteroid agonists as novel insect growth regulators. In: Casida JE (ed) Pesticides and alternatives: innovative chemical and biological approaches to pest control. Elsevier, Amsterdam, pp 251–257

    Google Scholar 

  • Wing KD, Slawecki RA, Carlson GR (1988) RH 5849, a nonsteroidal ecdysone agonist: effects on larval Lepidoptera. Science 241:470–472

    Google Scholar 

  • Wright JE, Retnakaran A (eds) (1987) Chitin and benzoylphenyl ureas. Dr. W. Junk, Dordrecht, p 309

    Google Scholar 

  • Yamamoto K, Chadarevian A, Pellegrini M (1988) Juvenile hormone action mediated in male accessory glands ofDrosophila by calcium and kinase C. Science 239:916–919

    Google Scholar 

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  1. Institut für Zoologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, W-4000, Düsseldorf 1, Germany

    Margarethe Spindler-Barth

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Spindler-Barth, M. Endocrine strategies for the control of ectoparasites and insect pests. Parasitol Res 78, 89–95 (1992). https://doi.org/10.1007/BF00931647

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