Summary
Elevated levels of insulin-like growth factor-binding protein (IGF-bp) were recently found in the serum of patients with ovarian tumors. We studied the concentration of IGF-bp in cyst fluids of 37 women operated on for benign or malignant ovarian cysts. The levels were elevated (>47 μg/l) in 6 of 28 benign, but in none of the nine malignant ovarian cysts. The highest IGF-bp concentration (447 μg/l) was observed in a benign serous cystadenoma.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bast RC Jr, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H, Berkowitz RS, Leavitt T, Griffiths T, Parker L, Zurawski WR, Knapp RC (1983) A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med 309:883–887
Baxter RC (1986) The somatomedins: insulin-like growth factors. Adv Clin Chem 25:49–115
de Bruijn HWA, Aalders JG, Kaner F, Duk MJ, van Beeck Calkoen-Carpay T, Fleuren GJ (1986) The biodistribution of CA 125 in the female genital tract. Tumour Biol 7:298
D'Ercole AJ (1985) Affinity-labeled plasma somatomedin-C insulin-like growth factor I binding proteins. Evidence of growth hormone dependence and subunit structure. J Clin Invest 75:1350–1355
Furlanetto RW (1980) The somatomedin C binding protein: evidence for a heterologous subunit structure. J Clin Endocrinol Metab 51:12–19
Iino K, Seppälä M, Heinonen PK, Sipponen P, Rutanen E-M (1986) Elevated levels of a somatomedin-binding protein 12 in patients with ovarian cancer. Cancer 58:2294–2297
Koistinen R, Kalkkinen N, Huhtala M-L, Seppälä M, Bohn H, Rutanen E-M (1986) Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid. Endocrinology 118:1375–1378
Seppälä M, Wahlström T, Koskimies AI, Tenhunen A, Rutanen E-M, Koistinen R, Huhtaniemi I, Bohn H, Stenman U-H (1984) Human preovulatory follicular fluid, luteinized cells of hyperstimulated preovulatory follicles, and corpus luteum contain placental protein 12. J Clin Endocrinol Metab 58:505–510
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Seppälä, M., Than, G. Insulin-like growth factor-binding protein PP12 in ovarian cyst fluid. Arch Gynecol Obstet 241, 33–35 (1987). https://doi.org/10.1007/BF00931438
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00931438