Abstract
Biochemical changes produced by luxabendazole in muscle-stageTrichinella spiralis larvae consisted of a decrease in free glucose and glycogen levels (46.71% and 35.66%, respectively) after in vivo treatment, slight in vitro inhibition of fumarate reductase activity (24.15%) and, finally, inhibition of [3H]-colchicine-tubulin binding, which was found to be of a competitive nature, with an inhibition constant (Ki) of 0.9×10−7 M. In a parallel study, luxabendazole did not appear to be inhibitory to [3H]-colchicine binding to pig-brain tubulin.
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Criado-Fornelio, A., de Armas-Serra, C., Jimenez-Gonzalez, A. et al. Biochemical effects of luxabendazole onTrichinella spiralis . Parasitol Res 76, 518–520 (1990). https://doi.org/10.1007/BF00931057
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DOI: https://doi.org/10.1007/BF00931057