Abstract
A monoclonal antibody raised against membrane proteins ofToxoplasma gondii with molecular weights of 35 and 21 kDa also reacts strongly and “specifically” with surface antigens ofPneumocystis carinii with molecular weights of 394.2 and 69 kDa when used in a direct immunofluorescence antibody test, on the one hand, and in a immunoblot after sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), on the other. Whether or not this observation might have any phylogenetic relevance remains open.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aspöck H, Hassl A (1990) Parasitic infections in HIV patients in Austria: first results of a long-term study. Zentralbl Bakteriol 272:540–546
Blumenfeld W, Mandrell RE, Jarvis GA, McLeod Griffiss J (1990) Localization of host immunoglobulin G to the surface ofPneumocystis carinii. Infect Immun 58:456–463
Budzko DB, Tyler L, Armstrong D (1989) Fc receptors on the surface ofToxoplasma gondii trophozoites: a confounding factor in testing for anti-Toxoplasma antibodies by indirect immunofluorescence. J Clin Microbiol 27:959–961
Hassl A, Aspöck H (1990) Antigens ofToxoplasma gondii recognized by sera of AIDS patients before, during, and after clinically important infections. Zentralbl Bakteriol 272:514–525
Koch G, Wohlfarth A, Müller WA (1989) Charakterisierung von monoklonalen Antikörpern gegenToxoplasma gondii. Z Gesamte Hyg 35:615–617
Kovacs JA, Halpern JL, Lundgren B, Swan JC, Parrillo JE, Masur H (1989) Monoclonal antibodies toPneumocystis carinii: identification of specific antigens and characterization of antigenic differences between rat and human isolates. J Infect Dis 159:60–70
Linke MJ, Cushion MT, Walzer PD (1989) Properties of the major antigens of rat and humanPneumocystis carinii. Infect Immun 57:1547–1555
Müller WA, Becker K, Schäfer A, Koch G, Borkhardt H-L (1988) Die Gewinnung von Hybridzellen, die monoklonale Antikörper gegenToxoplasma gondii produzieren. Angew Parasitol 29:11–17
Walker AN, Garner RE, Horst MN (1990) Immunocytochemical detection of chitin inPneumocystis carinii. Infect Immun 58:412–514
Walzer PD, Cushion MT (1989) Immunobiology ofPneumocystis carinii. Pathol Immunopathol Res 8:127–140
Watanabe J, Hori H, Tanabe K, Nakamura Y (1989) Phylogenetic association ofPneumocystis carinii with the “Rhizopoda/Myxomycota/Zygomycota group” indicated by comparison of 5S ribosomal RNA sequences. Mol Biochem Parasitol 32:163–168
Author information
Authors and Affiliations
Additional information
Dedicated to Prof. Dr. J. Eckert (Zürich) on the occasion of his 60th birthday
Rights and permissions
About this article
Cite this article
Hassi, A., Müller, W.A. & Aspöck, H. An identical epitope inPneumocystis carinii andToxoplasma gondii causing serological cross reactions. Parasitol Res 77, 351–352 (1991). https://doi.org/10.1007/BF00930914
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00930914