Abstract
A mathematical model based on kinetic data taken from the literature is presented for the pentose phosphate pathway in fasted rat liver steady-state. Since the oxidative and non oxidative pentose phosphate pathway can act independently, the complete (oxidative + non oxidative) and the non oxidative pentose pathway were simulated.
Sensitivity analyses are reported which show that the fluxes are mainly regulated by D-glucose-6-phosphate dehydrogenase (for the oxidative pathway) and by transketolase (for the non oxidative pathway). The most influent metabolites were the group ATP, ADP, P1 and the group NADPH, NADP+ (for the non oxidative pathway).
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Abbreviations
- GK:
-
Glucokinase, (E.C. 2.7.1.2.)
- G6PDH:
-
D-glucose-6-phosphate dehydrogenase, (E.C. 1.1.1.49)
- PLase:
-
6-Phosphogluconelactonase, (E.C. 3.1.1.31.)
- PGIcDH:
-
6-Phosphogluconate dehydrogenase, (E.C. 1.1.1.44)
- RPI:
-
D-ribose-5-phosphate keto-isomerase, (E.C. 5.3.1.6)
- TK:
-
D-sedoheptulose-7-phosphate: D-glyceraldehyde-3-phosphate glycol-aldehyde transferase, (E.C. 2.2.1.1.)
- TA:
-
D-sedoheptulose-7-phosphate: D-glyceraldehyde-3-phosphate dihydroxyacetone transferase, (E.C. 2.2.1.2)
- EP:
-
D-ribulose-5-phosphate-3′-epimerase, (E.C. 5.1.3.1)
- PGI:
-
D-glucose-6-phosphate keto-isomerase, (E.C. 5.3.1.9)
- TPI:
-
D-glyceraldehyde-3-phosphate keto-isomerase, (E.C.5.3.1.1)
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Sabate, L., Franco, R., Canela, E.I. et al. A model of the pentose phosphate pathway in rat liver cells. Mol Cell Biochem 142, 9–17 (1995). https://doi.org/10.1007/BF00928908
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DOI: https://doi.org/10.1007/BF00928908