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Effect of the 8-aminoquinoline primaquine on culture-derived gametocytes of the malaria parasitePlasmodium falciparum

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Abstract

Gametocytes from the Honduras I/CDC clone HB-3 ofPlasmodium falciparum were exposed to different concentrations of primaquine diphosphate. It could be shown that the drug acts specifically on the mitochondria of the cells by destroying their internal structure and causing these organelles to swell.

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Authors and Affiliations

  1. Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University Medical Center, 1501 Canal Street, 70112, New Orleans, LA, USA

    H. Norbert Lanners

  2. Delta Regional Primate Research Center, 18703 Three Rivers Road, 70433, Covington, LA, USA

    H. Norbert Lanners

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  1. H. Norbert Lanners
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Lanners, H.N. Effect of the 8-aminoquinoline primaquine on culture-derived gametocytes of the malaria parasitePlasmodium falciparum . Parasitol Res 77, 478–481 (1991). https://doi.org/10.1007/BF00928413

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  • DOI: https://doi.org/10.1007/BF00928413

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