Abstract
Plasmodium falciparum-infected human erythrocytes (early trophozoite stages) and non-infected erythrocytes were incubated in 1.7 mM 14C-desferrioxamine B (specific activity 1 μCi/2.6 mg desferrioxamine B). After 270 min the cells were washed and the radioactivity was measured in the cell pellet and, after lysis, in cytoplasm and membranes. The results indicate that Desferrioxamine B can the red blood cell and pass through the parasite membrane and that the parasites are killed by the intracellular action of the chelator.
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Fritsch, G., Jung, A. 14C-Desferrioxamine B: Uptake into erythrocytes infected withPlasmodium falciparum . Z. Parasitenkd. 72, 709–713 (1986). https://doi.org/10.1007/BF00925092
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DOI: https://doi.org/10.1007/BF00925092