Abstract
To evaluate the potential of interferon-alpha 2b (IFN-alpha) as an antifibrotic treatment after glaucoma filtering surgery, we studied its ability to inhibit mitogen-induced proliferation of human Tenon's capsule fibroblasts in vitro, as shown by [3H]-thymidine incorporation. IFN-alpha inhibited fetal calf serum-induced proliferation in a dose-dependent manner in concentrations ranging from 10 to 10000 IU/ml (P<0.001). Inhibition was also found when IFN-alpha was added prior to the mitogen (P=0.001); this inhibitory effect lasted at least 3 days. We suggest that IFN-alpha deserves further evaluation as a possible agent for the control of ocular fibrosis.
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Gillies, M., Su, T., Sarossy, M. et al. Interferon-alpha 2b inhibits proliferation of human Tenon's capsule fibroblasts. Graefe's Arch Clin Exp Ophthalmol 231, 118–121 (1993). https://doi.org/10.1007/BF00920225
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DOI: https://doi.org/10.1007/BF00920225