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Multiple paraneoplastic syndromes in a patient with antibodies to neuronal nucleoproteins (anti-Hu)

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Abstract

We report the clinical and autopsy studies of a patient with an unusual combination of multiple paraneoplastic neurological syndromes in association with antibodies to a 35–40 kDa neuronal nucleoprotein (anti-Hu). Neurological disease preceded the detection of a small cell carcinoma of the lung. The patient had combined sensory and motor neuronopathy or neuropathy, cerebellar degeneration, brain-stem and limbic encephalitis, and clinical evidence of the Lambert-Eaton myasthenic syndrome and gastrointestinal pseudo-obstruction of paraneoplastic origin.

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Author notes

  1. H. -P. Hartung

    Present address: Department of Neurology, Julius Maximilians University, Würzburg, Germany

Authors and Affiliations

  1. Neurologische Klinik, Medizinische Hochschule Hannover, D-30623, Hannover, Germany

    F. Heidenreich

  2. Department of Neurology, Heinrich Heine University, Postfach 101007, D-40001, Düsseldorf, Germany

    F. Heidenreich & H. -P. Hartung

  3. Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany

    R. Schober & U. Brinck

Authors
  1. F. Heidenreich
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  2. R. Schober
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  3. U. Brinck
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  4. H. -P. Hartung
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Heidenreich, F., Schober, R., Brinck, U. et al. Multiple paraneoplastic syndromes in a patient with antibodies to neuronal nucleoproteins (anti-Hu). J Neurol 242, 210–216 (1995). https://doi.org/10.1007/BF00919593

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  • DOI: https://doi.org/10.1007/BF00919593

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