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Experimental study on the fractionation schedule for proton irradiation of uveal melanoma

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Abstract

Greene melanoma in the anterior chamber of rabbits was irradiated by protons to find the isoeffect curve for proton irradiation fractionated into one, two, three or four doses. The isoeffect curve for tumor tissue remained constant between one- and three-dose fractionations and rose with four-dose fractionation. The isoeffect curve for normal tissue approximately followed the Ellis equation. Therefore, the optimal irradiation schedule should be in the range of three fractions because this best spares normal tissue while delivering a tumoricidal dose to the lesion. The relative reduction of the total dose from four- to one-dose fractions of intraoperative irradiation should be 20%.

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Authors and Affiliations

  1. Strahlenbiologisches Institut der Universität Zürich, Switzerland

    Gregor Wollensak & Hedi Fritz-Niggli

  2. Hôpital Ophtalmique, Université de Lausanne, Switzerland

    Leonidas Zografos

  3. Paul-Scherrer-Institute, Villigen, Switzerland

    Charles Perret & Emmanuel Egger

Authors
  1. Gregor Wollensak
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  2. Leonidas Zografos
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  3. Charles Perret
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  4. Emmanuel Egger
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  5. Hedi Fritz-Niggli
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Wollensak, G., Zografos, L., Perret, C. et al. Experimental study on the fractionation schedule for proton irradiation of uveal melanoma. Graefe's Arch Clin Exp Ophthalmol 228, 562–568 (1990). https://doi.org/10.1007/BF00918491

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  • DOI: https://doi.org/10.1007/BF00918491

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