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Protective effect of captopril on the blood-retina barrier in normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy

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Abstract

The effect of 18 months' inhibition of angiotensin-converting enzyme by captopril on the leakage of fluorescein through the blood-retina barrier was examined in a prospective, randomized control study of 20 normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy. After 18 months, 15 patients remained in the study. Fluorescein leakage remained nearly unchanged in the captopril-treated group, being 4.1 ± 4.1 (mean ± SD) × 10−7 cm/s at baseline and 4.2±4.1 × 10−7 cm/s after 18 months' treatment. The permeability increased significantly (P<0.01) from 3.3±2.2 × 10−7 cm/s to 5.6±3.5 × 10−7 cm/s at 18 months in the control group. Arterial blood pressure was nearly constant in both groups throughout the study. The results indicate that angiotensin-converting enzyme inhibition with captopril can arrest or delay a progressive breakdown of the blood-retina barrier in normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy.

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Authors and Affiliations

  1. Department of Ophthalmology, Gentofte Hospital, University of Copenhagen, DK-2900, Hellerup, Denmark

    Michael Larse & Henrik Lund-Andersen

  2. Hvidøre Hospital, Klampenborg, Denmark

    Eva Hommel & Hans-Henrik Parving

Authors
  1. Michael Larse
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  2. Eva Hommel
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  3. Hans-Henrik Parving
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  4. Henrik Lund-Andersen
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The authors have no commercial or proprietory interest in the drugs or instruments used in this study

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Larse, M., Hommel, E., Parving, HH. et al. Protective effect of captopril on the blood-retina barrier in normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy. Graefe's Arch Clin Exp Ophthalmol 228, 505–509 (1990). https://doi.org/10.1007/BF00918480

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  • DOI: https://doi.org/10.1007/BF00918480

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