Abstract
Pooled normal human IgG for therapeutic use, following depletion of anti-DNA, anti-Fc, and anti-F(ab′)2 of normal IgG, expressed antiidiotypic activity against anti-DNA derived from lupus sera. The antiidiotype enriched by elution from anti-DNA affinity columns bound directly to anti-DNA IgG and inhibited the binding of lupus sera to DNA but did not bind to normal IgG or inhibit the binding of anti-tetanus toxoid to tetanus toxoid. Antiidiotypes in pooled normal sera may have a role in the clinical improvement seen in patients with autoimmune diseases receiving intravenous immune globulin.
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Evans, M.J., Suenaga, R. & Abdou, N.I. Detection and purification of antiidiotypic antibody against anti-DNA in intravenous immune globulin. J Clin Immunol 11, 291–295 (1991). https://doi.org/10.1007/BF00918187
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DOI: https://doi.org/10.1007/BF00918187