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Properties of polyreactive natural antibodies to self and foreign antigens

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Conclusions

Natural polyreactive antibodies with the capacity to bind to both self and foreign antigens are present in the sear of healthy individuals. The B lymphocytes that secrete these antibodies belong to the subset of CD5+ B cells and may utilize a restricted set of VH and VL genes, strongly conserved during evolution. The role of these antibodies in the immune system is still a matter of debate. Further studies on their behavior in normal and autoimmune responses are required to elucidate this important issue.

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  1. Department of Clinical Immunology, University Hospital Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands

    Ton Logtenberg

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  1. Ton Logtenberg
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Logtenberg, T. Properties of polyreactive natural antibodies to self and foreign antigens. J Clin Immunol 10, 137–140 (1990). https://doi.org/10.1007/BF00917912

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