Abstract
The concentrations of the neuropeptides substance P, somatostatin, and calcitonin gene-related peptide in human nasal secretions were quantified by radioimmunoassays, concurrently with that of histamine, in the course of nasal challenge of allergic and control subjects with ryegrass antigen to examine contributions of neuromediation of the tissue response. Each of theneuropeptides and histamine were detected in nasal lavage fluid prior to challenge. In allergic patients, but not normal controls, antigen evoked significant increases of 3-fold in histamine at 15–60 min, 1.5- to 4-fold in calcitonin gene-related peptide at 15 min-24 hr, and more than 2-fold in somatostatin at 6 hr, without altering the concentration of substance P in nasal lavage fluid. The identity of the neuropeptides was confirmed chromatographically. Thus calcitonin gene-related peptide may mediate nasal congestion directly and somatostatin may be one of the factors regulating the late involvement of basophils and mast cells in allergic rhinitis.
Similar content being viewed by others
References
Lundberg JM, Franco-Cereceda A, Hua X, Hokfelt T, Fischer JA: Co-existence of substance P and calcitonin generelated peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. Eur J Pharmacol 108:315–319, 1985
Lundblad L: Protective reflexes and vascular effects in the nasal mucosa elicited by activation of capsaicin-sensitive substance P immunoreactive trigeminal neurons. Acta Physiol Scand Suppl 529:1–42, 1984
Hagermark O, Hokfelt T, Pernow B: Flare and itch induced by substance P in human skin. J Invest Dermatol 71:233–235, 1978
Goodman EC, Iversen LL: Calcitonin gene-related peptide: Novel neuropeptide. Life Sci 38:2169–2178, 1986
Payan DG, McGillis JP, Goetzl EJ: Neuroimmunology.In Advances in Immunology, FJ Dixon, KF Austen, L Hood, JW Uhr (eds). New York, Academic Press, 1986, pp 299–323
Druce HM, Wright RH, Rossoff D, Kaliner MA: Cholinergic nasal hyperreactivity in atopic subjects. Allergy Clin Immunol 76:445–452, 1985
Goetzl EJ, Chernov-Rogan T, Cooke MP, Renold F, Payan DG: Endogenous somatostatin-like peptides of rat basophilic leukemia cells. J Immunol 135:2707–2712, 1985
Goetzl EJ, Chernov-Rogan T, Furuichi K, Goetzl LM, Lee JY, Renold F: Neuromodulation of mast cell and basophil function.In Mast Cell Differentiation and Heterogeneity, AD Befus, J Bienenstock, JA Denberg (eds). New York, Raven Press, 1986, pp 223–229
Karlsson G, Pipkorn U, Andreasson L: Substance P and human nasal mucociliary activity. Clin Pharmacol 30:355–357, 1986
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Walker, K.B., Serwonska, M.H., Valone, F.H. et al. Distinctive patterns of release of neuroendocrine peptides after nasal challenge of allergic subjects with ryegrass antigen. J Clin Immunol 8, 108–113 (1988). https://doi.org/10.1007/BF00917898
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00917898