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T-cell abnormality and defective interleukin-2 production in patients with carcinoma of the urinary bladder with schistosomiasis

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Abstract

Patients with schistosomiasis of the urinary bladder (SB) and schistosomiasis with carcinoma of the urinary bladder (SCB) had significantly increased percentage of IL-2R-, HLA-DR-, and transferrin receptor (T9)-bearing T cells in circulation. The percentage of these activated T cells decreased byin vitro culture with PHA but increased bySchistosoma haematobium soluble egg antigen. These patients with SB and SCB had a PHA-specific defect in IL-2 production. A functional defect with induction of IL-2R-positive suppressor monocytes appears to correlate with the defective PHA-induced IL-2 production by CD4+ T cells and monocytes. Disordered regulation of PHA-induced IL-2 production by the CD4+ T cells and monocytes may be the key feature in the highly depressed cell-mediated immune response in schistosomiasis. However, immune activation and significantly elevated IL-2 production in response to disease-specificS. haematobium soluble egg antigen may be related with the pathogenesis of SB and SCB. Thus,S. haematobium-specific CD4+ T cells are present in schistosomiasis, and their function is determined by adequate release of IL-2-and/or IL-2R-bearing CD11+ suppressor monocytes.

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Authors and Affiliations

  1. Department of Clinical Immunology, and Department of Urology, King Saud University, College of Medicine, Abha, Saudi Arabia

    Syed Raziuddin, Sugandh Shetty & Ahmed Ibrahim

  2. Asir Central Hospital, Abha, Saudi Arabia

    Syed Raziuddin, Sugandh Shetty & Ahmed Ibrahim

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  1. Syed Raziuddin
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  2. Sugandh Shetty
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  3. Ahmed Ibrahim
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Raziuddin, S., Shetty, S. & Ibrahim, A. T-cell abnormality and defective interleukin-2 production in patients with carcinoma of the urinary bladder with schistosomiasis. J Clin Immunol 11, 103–113 (1991). https://doi.org/10.1007/BF00917746

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