Abstract
This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymesβ-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release significant (P < 0.05) amounts of the granular enzymes, but not of LDH in response to immunoglobulin G aggregates. There was no difference in the percent release exhibited by rheumatoid versus control neutrophils. Studies delineating the effects of rheumatoid factor sera and normal sera on aggregateinduced enzyme release revealed a significant negative correlation between the amount of rheumatoid factor in the sera and the percent release ofβ-glucuronidase and lysozyme but not of LDH. These studies thus demonstrate no abnormalities in rheumatoid neutrophil or rheumatoid serum enzyme activities or in neutrophil response to immunoglobulin G aggregates. They suggest, however, that rheumatoid factor may partially inhibit the release of lysosomal enzymes, thus suppressing this important component of the rheumatoid inflammatory process.
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Turner, R., Martin, M., Schroff, J. et al. Neutrophil enzyme activities in rheumatoid inflammation. Inflammation 3, 319–327 (1979). https://doi.org/10.1007/BF00914189
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DOI: https://doi.org/10.1007/BF00914189