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Rheumatoid factor and monosodium urate crystal-neutrophil interactions in gouty inflammation

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Abstract

A monolayer system was designed to study the interactions between human neutrophils and monosodium urate crystals important in gouty inflammation. The effects of rheumatoid factor on gouty inflammation were then examined in this system and in patients with acute gouty arthritis. Monosodium urate crystal phagocytosis was apparent at 30 min, and this phagocytosis was accompanied by lysosomal enzyme release and decreased neutrophil adherence to plastic petri dishes. Rheumatoid factor did not affect phagocytosis, adherence, or lactic dehydrogenase release and appeared to variably enhance lysosomal enzyme release. Two of 19 acute gouty patients were found to have low titers of rheumatoid factor and, of these, one exhibited mild disease and the other tophaceous destructive disease.

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Authors and Affiliations

  1. Rheumatology Section, Department of Medicine, Bowman Gray School of Medicine of Wake Forest University, 27103, Winston-Salem, North Carolina

    Robert A. Turner, Grace B. Counts, William J. Treadway, David A. Holt & Carlos A. Agudelo

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  1. Robert A. Turner
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  2. Grace B. Counts
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  3. William J. Treadway
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  4. David A. Holt
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  5. Carlos A. Agudelo
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Additional information

Supported in part by a Clinical Research Center grant from the Arthritis Foundation and a grant from the Easter Seal Research Foundation of the National Easter Seal Society for Crippled Children and Adults.

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Turner, R.A., Counts, G.B., Treadway, W.J. et al. Rheumatoid factor and monosodium urate crystal-neutrophil interactions in gouty inflammation. Inflammation 5, 353–361 (1981). https://doi.org/10.1007/BF00911099

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