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Suppression of human lymphocyte migration by PGE2

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Abstract

Prostaglandin (PG) E2 markedly inhibits casein- and C5a-stimulated lymphocyte migration in a concentration-dependent manner. Inhibition is observed with as low as 10−9 M PGE2 and requires that PGE2 be present during cell locomotion. Studies with PGE1, PGF1α, PGF2α and PGA1 indicate that only PGE1 and PGE2 inhibit lymphocyte migration. These studies indicate that PGE2 may play a role in the regulation of the immune response at the level of lymphocyte locomotion.

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Authors and Affiliations

  1. Departments of Medicine and Microbiology, University of New Mexico, School of Medicine, 87131, Albuquerque, New Mexico

    Dennis E. Van Epps

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  1. Dennis E. Van Epps
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Recipient of Senior Investigatorship from the Arthritis Foundation.

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Van Epps, D.E. Suppression of human lymphocyte migration by PGE2 . Inflammation 5, 81–87 (1981). https://doi.org/10.1007/BF00910782

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