Skip to main content
SpringerLink
Log in

Genetical effects of caffeine in mice

  • Published:
Zeitschrift für Vererbungslehre Aims and scope Submit manuscript

Summary

Caffeine administered orally in the drinking water as a 0.3% solution is not a very effective mutagen in the mouse. It may be mutagenic in its effects on male fertility, but it is ineffective in producing translocations that cause semisterility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature

  • Andrew, L. E.: The mutagenic activity of caffeine inDrosophila. Amer. Naturalist93, 135–138 (1959).

    Google Scholar 

  • Belitz, H. J.: Vergleichende Untersuchung der Verteilung spontaner und durch Chinon I (Bayer G 4073) induzierter Mutationen über die genetische Karte des X-Chromosoms vonDrosophila melanogaster. Z. indukt. Abstamm.-u. Vererb.-Lehre88, 434–442 (1957).

    Google Scholar 

  • Cattanach, B. M.: The sensitivity of the mouse testis to the mutagenic action of triethylenemelamine. Z. Vererb.-Lehre90, 1–6 (1959).

    Google Scholar 

  • Fahmy, O. G., andM. J. Fahmy: Cytogenetic analysis of the action of carcinogens and tumour inhibitors inDrosophila melanogaster. V. Differential genetic response to the alkylating mutagens and X-radiation. J. Genet.54, 146–164 (1956).

    Google Scholar 

  • Falconer, D. S.: The genetics of litter size in mice. J. cell. comp. Physiol.56, 153–167 (1960).

    PubMed  Google Scholar 

  • Fries, N., andB. Kihlman: Fungal mutations obtained with methyl xanthines. Nature (Lond.)162, 573–574 (1948).

    Google Scholar 

  • Glass, E. A., andA. Novick: Induction of mutation in chloramphenicol-inhibited bacteria. J. Bact.77, 10–16 (1959).

    PubMed  Google Scholar 

  • Haldane, J. B. S.: The detection of autosomal lethals in mice induced by mutagenic agents. J. Genet.54, 327–342 (1956).

    Google Scholar 

  • Kihlman, B., andA. Levan: The cytological effects of caffeine. Hereditas (Lund)35, 109–111 (1949).

    Google Scholar 

  • Lieb, M.: Enhancement of ultraviolet induced mutation in bacteria by caffeine. Z. Vererb.-Lehre92, 413–430 (1961).

    Google Scholar 

  • Lyon, M. F., R. J. S. Phillips andA. G. Searle: A test of mutagenicity of caffeine in mice. Z. Vererb.-Lehre93, 7–13 (1962).

    Google Scholar 

  • Novick, A., andL. Szilard: Genetic mechanisms in bacteria and bacterial viruses. I. Experiments on spontaneous and chemically induced mutations of bacteria growing in the chemostat. Cold Spr. Harb. Symp. quant. Biol.16, 337–343 (1951).

    Google Scholar 

  • Stieve, H.: Untersuchungen über die Wechselbeziehungen zwischen Gesamtkörper und Keimdrüsen. VI. Der Einfluß des Coffeins auf die Fortpflanzung des Russenkaninchens. Z. mikr.-anat. Forsch.15, 599–652 (1928).

    Google Scholar 

  • Welshons, W. T., B. H. Gibson andB. T. Scandlyn: Slide processing for the examination of male mammalian meiotic chromosomes. Stain, Techn.34, 1–5 (1962).

    Google Scholar 

  • Witkin, E. M.: Post-irradiation metabolism and the timing of ultraviolet-induced mutations in bacteria. Proc. X. Int. Congr. Genet.1, 280–299 (1958).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Animal Genetics, M.R.C. Mutagenesis Research Group, Edinburgh, 9, Scotland

    Bruce M. Cattanach

Authors
  1. Bruce M. Cattanach
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cattanach, B.M. Genetical effects of caffeine in mice. Zeitschrift für Vererbungslehre 93, 215–219 (1962). https://doi.org/10.1007/BF00889163

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00889163

Keywords

Search

Navigation