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Glycine metabolism in anaerobes

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Abstract

Some strict anaerobic bacteria catalyze with glycine as substrate an internal Stickland reaction by which glycine serves as electron donor being oxidized by glycine-cleavage system or as electron acceptor being reduced by glycine reductase. In both cases, energy is conserved by substrate level phosphorylation. Except for the different substrate-activating proteins P B , reduction of sarcosine or betaine to acetyl phosphate involves inEubacterium acidaminophilum the same set of proteins as observed for glycine, e.g. a unique thioredoxin system as electron donor and an acetyl phosphate-forming protein P c interacting with the intermediarily formed Secarboxymethylselenoether bound to protein P A .

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  1. Institute of Microbiology, University of Halle, Weinbergweg 16a, D-06099, Halle, Germany

    Jan R. Andreesen

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Andreesen, J.R. Glycine metabolism in anaerobes. Antonie van Leeuwenhoek 66, 223–237 (1994). https://doi.org/10.1007/BF00871641

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