Abstract
Acquired cystic kidney disease (ACKD) occurs in adult patients undergoing long-term dialysis. Early detection is important because clinically significant hematuria and malignancies are associated with ACKD. We evaluated by magnetic resonance imaging (MRI) and ultrasonography (US) the incidence of ACKD in 15 patients aged 7.3–21.6 years (mean 15.9 years) with non-cystic primary renal disease. Nine patients had been treated with peritoneal dialysis only, and 6 with both hemodialysis and peritoneal dialysis for 24–73 months (mean 37 months). Three patients (20%) had no cysts. In 5 patients (33%) with bilateral multiple cysts, the diagnosis of ACKD was made by MRI and US. In another 5 patients, solitary cysts were localized to one kidney by MRI, and in 2 patients solitary cysts were seen in both kidneys. This study documents that ACKD is not limited to older patients with end-stage renal disease. Early detection of these cysts can be accomplished by MRI and is warranted since 1 patient developed neoplastic tubular changes which can precede tumor formation.
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Dunnill MS, Millard PR, Oliver D (1977) Acquired cystic disease of the kidneys: a hazard of long-term intermittent maintenance haemodialysis. J Clin Pathol 30: 868–877
Ishikawa I, Saito Y, Onouchi A, Kitada H, Suzuki S, Kurihara S, Yuri T, Shinoda A (1980) Development of acquired cystic disease and adenocarcinoma of the kidney in glomerulonephritic chronic hemodialysis patients. Clin Nephrol 14: 1–6
Krempien B, Ritz E (1980) Acquired cystic transformation of the kidneys of haemodialyzed patients. Virchows Arch [A] 386: 189–200
Feiner HD, Kate LA, Gallo GR (1981) Acquired cystic disease of kidney in chronic dialysis patients. Urology 17: 260–264
Levine E, Grantham JJ, Slusher SL, Greathouse JL, Krohn BP (1984) CT of acquired cystic kidney disease and renal tumors in long-term dialysis patients. AJR 142: 125–131
Beardsworth SF, Goldsmith HJ, Ahmad R, Lamb G (1984) Acquisition of renal cysts during peritoneal dialysis. Lancet II: 1482
Mickisch O, Bommer J, Bachmann S, Waldherr R, Mann JFE, Ritz E (1984) Multicystic transformation of kidneys in chronic renal failure. Nephron 38: 93–99
Grantham JJ, Levine E (1985) Acquired cystic disease: replacing one kidney disease with another. Kidney Int 28: 99–105
Bansal VK, Ing TS, Cheifec G, Gandhi VC, Said R, Geis WP, Hano JE (1978) Dialysis-associated renal cystic degeneration. Kidney Int 14: 669
Ishikawa J, Yuri T, Kitada H, Shimoda A (1983) Regression of acquired cystic disease of the kidney after successful renal transplantation. Am J Nephrol 3: 310–314
Narasimhan N, Golper TA, Wolfson M, Rahatzad M, Bennett WM (1986) Climical characteristics and diagnostic considerations in acquired renal cystic disease. Kidney Int 30: 748–752
Goldsmith HJ, Ahmad R, Raichara N, Lal SM, McConnell CA, Gould DA, Gyde OHB, Green J (1982) Association between rising haemoglobin concentration and renal cysts formation in patients on long-term regular haemodialysis treatment. Proc Eur Dial Transplant Assoc 19: 313–318
Andersen BL, Curry NS, Gobien RP (1983) Sonography of evolving renal cystic transformation associated with hemodialysis. AJR 141: 1003–1004
Kutcher R, Amodio JB, Rosenblatt R (1983) Uremic renal cystic disease: value of sonographic screening. Radiology 147: 833–835
Koga N, Nomura G, Yamataga Y, Koga T (1982) Ureteric pain in patients with chronic renal failure on hemodialysis. Nephron 31: 55–58
Chalfin SA, Martin DC, Imray TJ, Pezzlo F (1981) Gross hematuria in a patient on chronic renal dialysis for the treatment of end-stage renal disease secondary to nephrosclerosis. Urology 126: 393–395
Shalboub RJ (1977) Retroperitoneal bleeding and dialysis. Ann Intern Med 86: 829
Ishikawa J, Shinoda A (1983) Renal adenocarcinoma with or without acquired cysts in chronic dialysis patients. Clin Nephrol 20: 321–322
Hughson MD, Buchwald D, Fox M (1986) Renal neoplasia and acquired cystic kidney disease in patients receiving long-term dialysis. Arch Pathol Lab Med 110: 592–601
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Leichter, H.E., Dietrich, R., Salusky, I.B. et al. Acquired cystic kidney disease in children undergoing long-term dialysis. Pediatr Nephrol 2, 8–11 (1988). https://doi.org/10.1007/BF00870371
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DOI: https://doi.org/10.1007/BF00870371