Abstract
Fifty-nine allografts were placed in 43 patients with renal failure from focal segmental glomerulosclerosis (FSGS): 27 allografts were put into 16 children aged less than 15 years, and 32 allografts into 27 adolescents and adults. Recurrence of FSGS was noted histologically in 13 allografts, 10 in 8 children and 3 in adults. None of the 9 children and 24 adults who never developed an allograft nephrotic syndrome showed FSGS in their allograft biopsies. The age of onset was a strong risk factor for recurrence: recurrent FSGS developed in 8 of 16 children (50%) but only in 11% of adolescents and adults (3 of 27 patients). Although the time from apparent onset to renal replacement treatment was shorter in those with recurrence than those without in the children, there was no difference in the time spent on dialysis prior to transplantation. Mesangial prominence was observed in the original biopsy in 12 of 13 patients with recurrence, and recurrence rate was similar in living and cadaver donor allografts; class I MHC matching was similar in those with and without recurrence. Three allografts treated with cyclosporin A as well as 9 with azathioprine showed recurrence. Of 9 second or subsequent allografts placed in those with recurrence in the first allograft, only 3 showed further recurence. rence. In 3 re-grafted after 13, 11 and 5 years, normal function was seen.
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Hoyer JR, Raij L, Vernier RL, Simmons RL, Najarian JS, Michael AF (1972) Recurrence of idiopathic nephrotic syndrome after renal transplantation. Lancet II:343–348
Mathew TH, Mathews DC, Hobbs JB, Kincaid-Smith P (1975) Glomerular lesions after renal transplantation. Am J Med 59:177–190
Kassirer J (principal discussant) (1976) Case records of the Massachusetts General Hospital. Case no 20-1976. N Engl J Med 294:1108–1115
Hamburger J, Crosnier J, Noel L-H (1978) Recurrent glomerulonephritis after renal transplantation. Annu Rev Med 19:67–72
Malekzadeh MH, Heuser ET, Ettenger RB, Pennisi AJ, Uitenbogaart CH, Warshaw BL, Fine RL (1979) Focal glomerulosclerosis and renal transplantation. J Pediatr 95: 249–254
Currier CB, Papadopoulou Z, Helfrich GB, Diaz MH, Sulkin MD (1979) Successful renal transplantation in focal segmental glomerulosclerosis. Transplant Proc 11: 49–54
Zimmerman CL (1980) Renal transplantation for focal segmental glomerulosclerosis. Transplantation 29:172
Leumann EP, Briner J, Donckerwolcke RAM, Kuijten R, Largiarder F (1980) Recurrence of focal segmental glomerulosclerosis in the transplanted kidney. Nephron 25: 65–71
Maizel SE, Sibley RK, Horstman JP, Kjellstrand CM (1981) Incidence and significance of recurrent focal segmental glomerulosclerosis in renal allograft recipients. Transplantation 32:511–516
Pinto J, Lacerda G, Cameron JS, Turner DR, Bewick M, Ogg CS (1981) Recurrence of focal segmental glomerulosclerosis in renal allografts. Transplantation 32:83–89
Chandra M, Lewy JE, Mouradian J, Susin M, Hoyer JR (1981) Recurrent nephrotic syndrome with three successive renal allografts. Am J Nephrol 1:110–114
Cheigh JS, Soleman M, Mouradian J, Tapia L, Riggio PR, Stubenbord W, Stenzel KH, Ruben AL (1981) Focal segmental glomerulosclerosis in kidney transplants. Transplant Proc 13:125–127
Morzycka M, Corker BP, Siegler HF, Tischler CG (1982) evaluation of recurrent glomerulonephritis in renal allografts. Am J Med 72:588–598
Lewis EJ (1982) Recurrent focal sclerosis after renal transplantation. Kidney Int 22:315–323
Alexsen RA, Seymour AE, Mathew TH, Fisher G, Canny A, Pascoe V (1984) Recurrent focal glomerulosclerosis in renal transplants. Clin Nephrol 21:110–114
Tornroth T (1984) Recurrent and de novo glomerulonephritis in allografted kidneys: aspects of ultrastructural diagnosis. Appl Pathol 5:88–94
Hosenpud J, Piering WF, Garancis JC, Kauffman HM (1985) Successful second kidney transplantation in a patient with focal glomerulosclerosis: a case report. Am J Nephrol 5:299–304
Striegel JE, Sibley RK, Fryd DS, Mauer SM (1986) Recurrence of focal segmental sclerosis in children following renal transplantation. Kidney Int 29 [Suppl 19] S-44–S-50
Verani RR, Hawkins EP (1986) Recurrent focal segmental glomerulosclerosis, a pathological study of the early lesion. Am J Nephrol 6:263–270
Habib R, Gagnadoux M-F, Broyer M (1987) Recurrent glomerulonephritis in transplanted children. Contrib Nephrol 55:123–125
Morales JM, Andres A, Prieto C, Martiez MA, Praga M, Rullope LM, Guiterrez Millet V, Rodicio J (1988) Clinical and histological sequence of recurrent focal segmental glomerulosclerosis. Nephron 48:241–242
Korbet SM, Schwartz MM, Lewis EJ (1988) Recurrent nephrotic syndrome in renal allografts. Am J Kidney Dis 11: 270–276
Habib R, Bois E (1975) Congenital and infantile nephrotic syndrome. In: Strauss J (ed) Pediatric nephrology, vol. 2. Stratton Intercontinenta, New York, pp 355
Donckerwolcke RA, Broyer M, Brunner FP, Brynger H, Jacobs C, Kramer P, Selwood NH, Wing AJ (1982) Combined report on regular dialysis and tranplantation of children in Europe, XI, 1981. Proc Eur Dial Transplant Assoc 19:61–86
Munoz J, Sanchez R, Perez Garcia R, Anaya F, Valderrabano F (1985) Recurrent focal segmental glomerulosclerosis in renal transplants. Proteinuria relapsing following plasma exchange. Clin Nephrol 24:213–214
Zimmerman SW, Mann S (1984) Increased urinary protein excretion in the rat produced by serum from a patient with recurrent focal glomerular sclerosis after renal transplantation. Clin Nephrol 22:32–38
Laufer J, Ettenger RB, Ho WG, Cohen AH, Marik JL, Fine RN (1988) Plasma exchange for recurrent nephrotic syndrome following renal transplantation. Transplantation 46:540–542
Torres VE, Velosa JA, Holley KE, Frohnert PP, Zincke H, Sterioff S (1984) Meclofenamate treatment of recurrent idiopathic nephrotic syndrome with focal segmental glomerulosclerosis after renal transplantation. Mayo Clin Proc 59:146–152
Voets AJ, Hoitsma AJ, Koene RAP (1986) Recurrence of nephrotic syndrome during cyclosporin treatment after renal transplantation. Lancet I:266–267
Pirson Y, Squifflet JP, Marbaix E, Alexandre GP, van Ypersele de Strihou C (1986) Recurrence of focal glomerulosclerosis despite cyclosporine treatment after renal transplantation. Br Med J 292:1336
Habib R, Antignac C, Hinglais N (1987) Glomerular lesions in the transplanted kidney in children. Am J Kidney Dis 10:198–207
Cameron JS (1982) Glomerulonephritis in renal transplants. Transplantation 34:237–245
Mathew TH (1988) Recurrence of disease following renal transplantation. Am J Kidney Dis 12:85–93
Fine RN, Tejani A (1987) Renal transplantation in children. Nephron 47:87–96
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Senggutuvan, P., Cameron, J.S., Hartley, R.B. et al. Recurrence of focal segmental glomerulosclerosis in transplanted kidneys: Analysis of incidence and risk factors in 59 allografts. Pediatr Nephrol 4, 21–28 (1990). https://doi.org/10.1007/BF00858431
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DOI: https://doi.org/10.1007/BF00858431