Abstract
Thirteen infants received their first renal transplant at the University of Minnesota from 1978 through 1985. Nine of the originally transplanted kidneys are still functioning and only two patients have died. These results are similar to those obtained in larger groups of children either less than 2 years of age or less than 5 years of age at the time of transplantation. Successfully transplanted infants experience accelerated growth and development, frequently reaching the normal range for their age. Since both chronic uremia and dialysis carry special risks in infancy, the option of earlier transplantation should be considered in any infant with end-stage renal failure.
Similar content being viewed by others
References
Hoyer JR, Ratte J, Potter AH, Michael AF (1972) Transfer of aminonucleoside nephrosis by renal transplantation. J Clin Invest 51:2777–2780
Kohaut EC, Alexander SR, Mehls O (1985) The management of the infant on CAPD. In: Fine RN, Schärer K, Mehls O (eds) Springer, Berlin Heidelberg New York pp 97–105
Nevins TE, Mauer SM (1984) Infant hemodialysis. In: Fine RN, Gruskin AB (eds) ESRD in children. W. B. Saunders, Philadelphia, pp 39–53
Miller LC, Lum CT, Bock GH, Simmons RL, Najarian JS, Mauer SM (1983) Transplantation of the adult kidney into the very small child. Am J Surg 145:243–347
So SKS, Chang P-N, Najarian JS, Mauer SM, Simmons RL, Nevins TE (1987) Growth and development in infants after renal transplantation. J Pediatr (in press)
Najarian JS, So SKS, Simmons RL, Fryd DS, Nevins TE, Ascher NL, Sutherland DER, Payne WD, Chavers BC, Mauer SM (1986) The outcome of 304 primary renal transplants in children (1968–1985). Ann Surg 204: 246–258
Moel DL, Butt KMH (1981) Renal transplantation in children less than 2 years of age. J Pediatr 99:535–539
Rotundo A, Nevins TE, Lipton M, Lockman LA, Mauer SM, Michael AF (1981) Progressive encephalopathy in children with chronic renal insufficiency in infancy. Kidney Int 21:686–691
Baluarte HJ, Gruskin AB, Hiner LB, Foley CM, Grover WD (1977) Encephalopathy in children with chronic renal failure. Proc Clin Dial Transplant Forum 7:95–97
Bale JF Jr, Siegler RL, Bray PF (1980) Encephalopathy in young children with moderate chronic renal failure. Am J Dis Child 134:581–583
Chavers B, Knaak M, Nevins T, Melvin T, Mauer SM (1986) Early ATN, late rejection in pediatric renal transplantation with donor specific transfusion. XI Int Congr Transplant Soc (abstract)
Nevins TE, Knaak M, So SKS, Chavers B, Melvin T, Simmons RL, Mauer SM, Najarian JS (1986) Preliminary results of low-dose Cyclosporine A in pediatric renal transplantation. Int J Pediatr Nephrol 7:91–95
Rizzoni G, Malekzadeh MH, Pennisi AJ, Ettenger RB, Vittenbogaart CH, Fine RN (1981) Renal transplantation in children less than 5 years of age. Arch Dis Child 55: 532–536
Trompeter RS, Bewick M, Haycock GB, Chantler C (1983) Renal transplantation in very young children. Lancet I:373–375
Nevins T, Chang P-N, Mauer SM (1984) Renal transplantation in the very young child. In: Tune BM, Mendoza SA, Brenner BM, Stein JH (eds) Contemporary issues in nephrology, vol 12. Churchill-Livingstone, New York, pp 381–397
Kohaut EC, Whelchel JR, Waldo FB, Diethelm AG (1985) Living-related donor renal transplantation in children presenting with end-stage renal disease in the first month of life. Transplantation 40:725–726
Author information
Authors and Affiliations
Additional information
Supported in part by NIH grants (HD17286, RR400, AM13083)
Rights and permissions
About this article
Cite this article
Nevins, T.E. Transplantation in infants less than 1 year of age. Pediatr Nephrol 1, 154–156 (1987). https://doi.org/10.1007/BF00849287
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00849287