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Pattern specification in imaginal discs ofDrosophila melanogaster

Developmental analysis of a temperature-sensitive mutant producing duplicated legs

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Summary

l(1)su(f)mad-ts (mad) is a new temperature-sensitive (ts) lethal mutant ofDrosophila melanogaster which produces duplicated legs after temperature pulse treatment during larval development. The ts-lethality was studied in temperature experiments and genetic mosaics. Temperature pulses given during two distinct TSPs of larval development result in two different types of leg pattern duplication. “Total” differ from “partial” duplications with respect to the affected leg compartments and the orientation of the planes of symmetry which are perpendicular to the dorso-ventral and the proximo-distal leg axes in total and partial duplications, respectively. Genetic mosaic studies indicate (i) disc autonomy of leg pattern duplication, (ii) clonal separation of the anlagen of the two pattern copies, and (iii) clonal restriction along the antero-posterior compartment border in the two pattern copies of totally duplicated legs.

The results suggest thatmad leg pattern duplication is caused by a change in positional information rather than by cell death and subsequent regeneration. Our data are compatible with the assumption that during normal development the leg disc cells acquire information about their position within the disc with respect to the different leg axes independently and at different times.

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Author notes

  1. Gerd Jürgens

    Present address: Biologisches Institut III, Universität Freiburg, Schänzlestr. 1, D-7800, Freiburg i.Br., Bundesrepublik Deutschland

Authors and Affiliations

  1. Biologisches Institut I (Zoologie), Universität Freiburg i. Br., Schänzlestraße 1, D-7800, Freiburg, Federal Republic of Germany

    Gerd Jürgens & Elisabeth Gateff

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  1. Gerd Jürgens
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  2. Elisabeth Gateff
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Jürgens, G., Gateff, E. Pattern specification in imaginal discs ofDrosophila melanogaster . Wilhelm Roux' Archiv 186, 1–25 (1979). https://doi.org/10.1007/BF00848105

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  • DOI: https://doi.org/10.1007/BF00848105

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