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Lipid peroxidation in a focus of hyperactivity in the rat cerebral cortex

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that lipid peroxidation (LPO) can participate in the mechanism of development of paroxysmal activity in the rat cerebral cortex. The appearance of epileptic activity as a result of application of the sodium salt of penicillin to the surface of the sensomotor cortex led to a sharp rise in LPO products in the fraction of unpurified synaptosomes isolated from a focus of hyperactivity. Preliminary injection of the antioxidant α-tocopherol into rats abolished the LPO activation effect and considerably reduced the number of paroxysms recorded on the electrocorticogram during existence of the focus.

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Authors
  1. G. N. Kryzhanovskii
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  2. E. V. Nikushkin
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  3. V. E. Braslavskii
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  4. R. N. Glebov
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Additional information

Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 1, pp. 14–16, January, 1980.

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Kryzhanovskii, G.N., Nikushkin, E.V., Braslavskii, V.E. et al. Lipid peroxidation in a focus of hyperactivity in the rat cerebral cortex. Bull Exp Biol Med 89, 16–19 (1980). https://doi.org/10.1007/BF00835488

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  • DOI: https://doi.org/10.1007/BF00835488

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