References
Asano M, Yukita A, Matsumoto T, Kondo S, Suzuki H (1995) Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor 121. Cancer Res 55:5296
Baselga J, Fan Z, Norton L, Mendelsohn J (1994) Monoclonal antibodies directed against growth factor receptors enhance the efficacy of chemotheapeutic agents. Ann Oncol 5 [Suppl 5]:abstr no. 010
Baselga J, Mendelsohn J (1994) Receptor blockade with monoclonal antibodies as anti-cancer therapy. Pharmacol Ther 64:127
Baselga J, Norton L, Masui H, et al (1993) Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J Natl Cancer Inst 85:1327
Baselga J, Tripathy D, Mendelsohn J, et al (1996) Phase II study of weekly intravenous recombinant humanized anti-P185 (HER2) monoclonal antibody in patients with HER2/NEU overexpressing metasta breast carcinoma. J Clin Oncol 14:737
Bikfalvi A (1995) Significance of angiogenesis in tumour progression and metastasis. Eur J Cancer 31A:1101
Caron P, Lai L, Scheinberg D (1995) Interleukin-2 enhancement of cytotoxicity by humanized monoclonal antibody M195 (anti-CD33) in myelogenous leukemia. Clin Cancer Res 1:63
Chamow S, Ashkenazi A (1996) Immunoadhesins: principles and applications. Trends Biotechnol 14:52
Chester K, Hawkins R (1995) Clinical issues in antibody design. Trends Biotechnol 13:294
Coney LR, Daniel PT, Sanborn D (1994) Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression. Int J Cancer 58:562
Everson TC (1967) The spontaneous regression of cancer. Prog Clin Cancer 3:79
Fagerberg J, Hjelm A, Ragnhammar P, Frodin J, Wigzell H, Mellstedt H (1995) Tumor regression in monoclonal antibody-treated patients correlates with the presence of anti-idiotype-reactive T lymphocytes. Cancer Res 55:1824
Fagerberg J, Steinitz M, Wigzell H, Askelsf P, Mellstedt H (1995) Human anti-idiotypic antibodies induced a Immoral and cellular immune response against a colorectal carcinoma-associated antigen in patients. Proc Natl Acad Sci USA 92:4773
Fan Z, Masui H, Baselga J, Mendelsohn J (1993) Antitumor effect of anti-EGF receptor monoclonal antibodies is enhanced by combination treatment with cis-platinum. Proc Anna Meet Am Assoc Cancer Res 34:abstr no. A 2037
Fogler WE, Klinger MR, Abraham KG, Gottlinger HG, Riethmüller G, Daddona PE (1988) Enhanced Cytotoxicity against colon carcinoma by combinations of noncompeting monoclonal antibodies to the 17-1A antigen. Cancer Res 48:6303
Foon KA, Maluish AE, Abrams PG, et al (1986) Recombinant leukocyte A interferon therapy for advanced hairy cell leukemia: therapeutic and immunologic results. Am J Med 80:351
Frankel A, FitzGerald D, Siegall C, Press O (1996) Advances in immunotoxin biology and therapy: a summary of the fourth international symposium on immunotoxins. Cancer Res 56:926
Göttlinger HG, Funke I, Johnson JF, Gokel JM, Riethmüller G (1986) The epithelial cell surface antigen 17-1A, a target for antibody-mediated tumor therapy: its biochemical nature, tissue distribution and recognition by different monoclonal antibodies. Int J Cancer 38:47
Grossbard ML, Press OW, Applebaum FR, Bernstein ID, Nadler LM (1992) Monoclonal antibodybased therapies of leukemia and lymphoma. Blood 80:863
Holz E, Gruber R, Riethmüller G (1996) Monoclonal antibodies in cancer therapy: new perspectives after the colorectal carcinoma trial. Clin Immunother 5:214
Knox S (1995) Overview of studies on experimental radioimmunotherapy. Cancer Res [Suppl] 55:5832s
Koprowski H, Herlyn D, Rubeck M, Defreitas M, Sears HF (1984) Human anti-idiotype antibodies in cancer patients: is the modulation of the immune response beneficial for the patient? Proc Natl Acad Sci USA 81:216
Lanzavecchia A, Abrignani S, Scheidegger D, Obrist R, Dörken B, Moldenhauer G (1988) Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets. J Exp Med 167:345
Lindemann F, Schlimok G, Dirschedl P, Witte J, Riethmüller G (1992) Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet 340:685
Litvinov S, Velders M, Bakker H, Fleuren G, Warnaar S (1994) Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol 125:437
Mack M, Riethmüller G, Kufer P (1995) A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc Natl Acad Sci USA 92:7021
Maruyama H, Benden A, Li W, et al (1996) Monoclonal anti-idiotypic antibody functionally mimics the human gastrointestinal carcinoma epitope GA733. Int J Cancer 65:547
Matzinger P (1994) Tolerance, danger, and the extended family. Ann Rev Immunol 12:991
Mellstedt H, Frödin JE, Masucci G, et al (1991) The therapeutic use of monoclonal antibodies in colorectal carcinoma. Semin Oncol 1:462
Melton R, Sherwood R (1996) Antibody-enzyme conjugates for cancer therapy. J Natl Cancer Inst 88:153
Minasian L, Tzy-Jyun-Yao Y, Steffens T, Scheinber D, et al (1995) A phase I study of anti-GD3 ganglioside monoclonal antibody R24 and recombinant human macrophage-colony stimulating factor in patients with metastatic melanoma. Cancer 75:2251
Moertel C, Fleming T, Macdonald J, et al (1995) Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Ann Intern Med 122:321
Oosterwijk E, Bander N, Divgi C, et al (1993) Antibody localization in human renal cell carcinoma: a phase I study of monoclonal antibody G250. J Clin Oncol 11:738
O'Connell M, Laune J, Shepher L, et al (1996) A prospective evaluation of chemotherapy duration and regimen as surgical adjuvant treatment for high-risk colon cancer: a collaborative trial of the north central cancer treatment group and the national cancer institute of canada clinical trials group. J Clin Oncol ASCO-Meeting:abstr no. 478
Pieteresz GA, McKenzie IFC (1992) Antibody conjugates for the treatment of cancer. Immunol Rev 129:57
Ragnhammar P, Fagerberg J, Frödin JE (1993) Effect of monoclonal antibody 17-1A and GM-CSF in patients with advanced colorectal carcinoma - long-lasting, complete remissions can be induced Int J Cancer 53:751
Ranghammer P, Fagerberg J, Frodin J, Wersall P, Hansson L, Mellstedt H (1995) Granulocyte/macrophage-colony-stimulating factor augments the induction of antibodies, especially anti-idiotypic antibodies, to therapeutic monoclonal antibodies. Cancer Immunol Immunother 40:367
Ravetch JV, Kinet J-P (1991) Fe receptors. Annu Rev Immunol 9:457
Rees A, Stauton D, Webster D, Searle S, Henry A, Pedersen J (1994) Antibody design: beyond the natural limits. Trends Biotechnol 12:199
Reiter Y, Pastan I (1996) Antibody engineering of recombinant Fv immunotoxins for improved targeting of cancer: disulfide-stabilized Fv immunotoxins. Clin Cancer Res 2:245
Riethmüller G, Schneider-Gödicke E, Johnsen JP (1993) Monoclonal antibodies in cancer therapy. Curr Opin Immunol 5:732
Riethmüller G, Schneider-Gödicke E, Schlimok G, et al (1994) Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. Lancet 343:1177
Rivoldni L, Kawakami Y, Sakaguchi K, et al (1995) Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MARTA. J Immunol 154:2257
Rosenberg SA (1992) The immunotherapy and gene therapy of cancer. J Clin Oncol 10:180
Rosenberg SA (1993) Principles and applications of biologic therapy. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology. Lippincott, Philadelphia, pp 293–324
Saga T, Neumann R, Heya T, et al (1995) Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. Proc Natl Acad Sci USA 92:8999
Saleh M, Khazaeli M, Wheeler R, et al (1995) Phase II trial of murine monoclonal antibody D612 combined with recombinant human monocyte colony-stimulating factor (rh-M-CSF) in patients with metastatic gastrointesinal cancer. Cancer Res 55:4330
Santoro L, Reboul A, Kerblat I, Droner C, Colomb M (1996) Monoclonal IgG as antigen: reduction is an early intracellular event of their processing by antigen-presenting cells. Int Immunol 8:211
Schlimok G, Funke I, Holzmann B, et al (1987) Micrometastatic cancer cells in bone marrow: in vitro detection with anti- cytokeratin and in vivo labeling with anti-17-1A monoclonal antibodies. Med Sci 84:8672
Schlimok G, Pantel K, Loibner H, Fackler-Schwalbe I, Riethmüller G (1995) Reduction of metastatic carcinoma cells in bone marrow by intravenously administered monoclonal antibody: towards a novel surrogate test to monitor adjuvant therapies of solid tumours. Eur J Cancer 31A:1799
Tai-Ping D, Jaggar R, Bicknell R (1995) Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends Pharmacol Sci 16:57
Theodoulou M, Gilewski T, Welt S, et al (1994) Anti-Lewis Y (LeY) monoclonal antibody (mAb) BR55-2 (IgG2a) in patients with advanced breast cancer. Proc Annu Meet Am Soc Clin Oncol 13:abstr no. A974
Van Den Eynde B, Hainaut P, Herin M, et al (1989) Presence on a human melanoma of multiple antigens recognized by autologous CTL. Int J Cancer 44:634
Vitetta E, Thorbe P, Uhr J (1993) Immunotoxins: magic bullets or misguided missiles? Immunol Today 14:252
Welt S, Divgi C, Scott A, et al (1994) Antibody targeting in metastatic colon cancer: a phase I study of monoclonal antibody F19 against a cell-surface protein of reactive tumor stromal fibroblasts. J Clin Oncol 12:1193
Wu X, Fan Z, Masui H, Rosen N, Mendelsohn J (1995) Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest 95:1897
Zhang S, Helling F, Lloyd K, Linvingston P (1995) Increased tumor cell reactivity and complement-dependent cytotoxicity with mixtures of monoclonal antibodies against different gangliosides. Cancer Immunol Immunother 40:88
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gruben, R., Holz, E. & Riethmüller, G. Monoclonal antibodies in cancer therapy. Springer Semin Immunopathol 18, 243–251 (1996). https://doi.org/10.1007/BF00820669
Issue Date:
DOI: https://doi.org/10.1007/BF00820669