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Natural and induced regulation of Th1/Th2 balance

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Summary

Because Th1/Th2 balance is perturbed during immunological disease, the design of strategies aiming at its rectification has become a priority. The alteration of the balance in pregnancy so as to promote survival of the fetal allograft lends credibility to this aim. Attenuation of the activation signal delivered through the T cell receptor (TCR) represents a promising approach. It is supported by the high level of polymorphism in the MHC class II promoter, which regulates the natural TCR signal and thus modulates Th1/Th2 differentiation. Further support comes from the Th2 shift that occurs in JNK knockout mice, and with kinase inhibitors and anti-CD4 monoclonal antibodies applied in vitro. The approach has implications for nasal tolerance and inhibition of IL-12 production. The further range of options for Th1/Th2 modulation, which are presented throughout this issue of the journal, are here summarised and evaluated.

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Authors and Affiliations

  1. Department of Immunology, University College London, Windeyer Institute of Medical Sciences, 46 Cleveland Street, W1P 6DB, London, UK

    N. A. Mitchison

  2. Deutsches Rheuma Forschungs Zentrum, Berlin, Germany

    D. Schuhbauer

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  1. N. A. Mitchison
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  2. D. Schuhbauer
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  3. B. Müller
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Mitchison, N.A., Schuhbauer, D. & Müller, B. Natural and induced regulation of Th1/Th2 balance. Springer Semin Immunopathol 21, 199–210 (1999). https://doi.org/10.1007/BF00812253

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