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Structure, molecular genetics, and evolution of vacuolar H+-ATPases

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Abstract

Proton-ATPases can be divided into three classes denoted as P-, F-, and V-ATPases. The P-ATPases are evolutionarily distinct from the F- and V-type ATPases which have been shown to be related, probably evolved from a common ancestral enzyme. Like F-ATPases, V-ATPases are composed of two distinct structures: a catalytic sector that is hydrophilic in nature and a hydrophobic membrane sector which functions in proton conduction. Recent studies on the molecular biology of vacuolar H+-ATPases revealed surprising findings about the evolution of pronon pumps as well as important clues for the evolution of eukaryotic cells.

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  1. Roche Institute of Molecular Biology, Roche Research Center, 07110, Nutley, New Jersey

    Nathan Nelson

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Nelson, N. Structure, molecular genetics, and evolution of vacuolar H+-ATPases. J Bioenerg Biomembr 21, 553–571 (1989). https://doi.org/10.1007/BF00808113

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