Summary
The sensitivity of several cultured neuroblastoma cell lines toL-glutamate (Glu) and its analogues has been studied with the whole-cell patch clamp technique. Only in the neuroblastoma cell line N2A Glu induced a concentration dependent response consisting of an inward current. In addition, N2A cells responded to superfusion with kainate, quisqualate orN-methyl-D-aspartate, but to a lesser degree than to Glu. It is concluded that N2A cells could be useful as anin vitro model to study excitatory amino acid properties.
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van der Valk, J.B.F., Vijverberg, H.P.M. Neuroblastoma cells as possible model in the study of glutamate receptors. Amino Acids 1, 91–95 (1991). https://doi.org/10.1007/BF00808095
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DOI: https://doi.org/10.1007/BF00808095