Summary
Taurine which has antioxidant effects is also known to have effects on cell proliferation, inflammation and collagenogenesis. The aim of this study was to investigate the effect of taurine on incisional skin wounds.
The mice incised on the dorsal area were divided into control and experimental groups. Saline was injected intraperitoneally to half of the animals in the control group and locally applied to the other half. Fifty mM taurine solution was given intraperitoneally to the first half of the experimental animals and locally to the second half of the experimental group.
After four days of treatment, malondialdehyde (MDA) and histamine levels as well as the tensile strength of the wound tissue were measured. Structural alterations in epidermis and dermis were histologically evaluated.
The locally administreated taurine significantly increased wound tensile strength by decreasing the MDA and histamine levels and prevented the degranulation of the mast cells. These observations suggest that taurine may be useful on wound healing.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alvarez JG, Storey BT (1983) Taurine, hypotaurine and albumin inhibit lipid peroxidation in rabbit spermatozoa and protect against loss of motility. Biol Repro 29: 548–555
Basaga HS (1990) Biochemical aspects of free radicals. Biochem Cell Biol 68: 989–998
Bergren ST, Bodzin JH, Cortes JA (1988) Improved survival using oxygen free radical scavengers in the presence of ischemic bowel anastomosis. Am Surg 54: 333–336
Çelebi N, Erden N, Gönül B, Koz M (1994) Effects of epidermal growth factor dosage forms on dermal wound strength. J Pham Pharmacol 46: 386–387
Dabrowski R, Maslinski C (1981) The role of histamine in wound healing. The effect of antagonists and agonists of histamine receptors (H1 and H2) on collagen levels in granulation tissue. Agents Actions 11: 122–124
Faiman MD (1986) Pulmonary oxygen toxicity in the rat and the role of histamine. Biochem Pharmacol 35: 3889–3892
Fitzpatrick DW, Fisher H (1982) Histamine synthesis imidazole dipeptides, and wound healing. Surgery 91: 430–434
Foschi D, Trabucchi E, Musozzi M, Castoldi L, Di Mattia D, Rodaelli E, Marazzi M, Franzini P, Berlusconi A (1988) The effects of oxygen free radicals on wound healing. Int J Tissue React 10: 373–379
Ginsberg MD, Watson BD, Busto R, Yashida S, Prado R, Nakayama H, Ikeda M, Dietrich WD (1988) Peroxidative damage to cell membranes following cerebral ischemia. Neurochem Pathol 9: 171–193
Gordon RE, Shaked AA, Solano DF (1986) Taurine protects hamster bronchioles from acute NO2 induced alterations. Am J Pathol 125: 585–600
Harada H, Cusack BJ, Olson RD, Strou W, Azumo J, Hamaguchi T, Schaffer SW (1990) Taurine defficiency and doxorubicin: interaction with the cardiac sarcolemmal calcium pump. Biochem Pharmacol 39: 745–751
Henderson WR, Kaliner M (1978) Immunologic and nonimmunologic generation of superoxide from mast cells on basophils. Clin Invest 61: 187–196
Högstrom H (1987) Mechanisms and prevention of decrease in wound margin strength. Acta Chir Scand [Suppl] 539: 5–63
Hunter EG (1989) Adult ventricular myocytes isolated from CHF 146 and CHF 147 cardiomyopathic hamsters. Proc Soc Exp Biol Med 190: 330–338
Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72: 101–163
Huxtable R, Bressler R (1973) Effect of taurine on a muscle intracellular membrane. Biochem Biophys Acta 323: 573–583
Januszkiewicz AJ, Faiman MD (1984) The fact ofin vivo hyperoxic exposure on the release of endogenous histamine from the rat isolated perfused lung. Toxicol Appl Pharmacol 72: 134–141
Jeffrey JJ (1992) Collagen degradation. In: Cohen K, Diegelman RF, Lindblad WJ (eds) Wound healing: biochemical and clinical aspects. W.B. Saunders Company, Philadelphia, p 186
Kahlson G, Nilsson K, Rosengren E, Zederfeldt B (1960) Wound healing-as dependent on rate of histamine formation. Lancet: 230–234
King SR, Hickerson WL, Proctor KG, Newsome AM (1991) Beneficial actions of exogenous hyaluronic acid on wound healing. Surgery 109: 76–84
Kuriyama K (1980) Taurine as a neuromodulator. Fedn Proc 39: 2680–2684
Mannaioni PF, Gianella E, Polmerani B, Pistelli A, Gambassi F, Bani-Sacchi T, Bianchi S, Masini E (1988) Free radicals as endogeneous histamine releasers. Agents Actions 23: 130–142
Nakashima T, Taniko T, Kuriyama K (1982) Therapeutic effect of taurine adminstration on carbon tetrachloride-induced hepatic injury. Jpn J Pharmacol 32: 583–589
Nakashima T, Takino T, Kuriyama K (1983) Therapeutic and prophylactic effects of taurine adminstration on experimental liver injury. In: Kuriyama K, Huxtable HJ, Iwata H (eds) Sulphur amino acids: biochemical and clinical aspects. Alan R. Liss, Inc., New York, pp 449–459
Pasantes-Morales H, Wright CE, Gaull GE (1984) Protective effect of taurine, zinc and tocopherol on retinol-induced damage in human lymphoblastoid cells. J Nutr 114: 2256–2261
Pasantes-Morales H, Wright CE, Gaull GE (1985) Taurine protection of lymphoblastoid cells from iron-ascorbate induced damage. Biochem Pharmacol 34: 2205–2206
Pasantes-Morales H, Cruz C (1985) Taurine and hypotaurine inhibit light-induced lipid peroxidation and protect rod outer segment structure. Brain Res 330: 154–157
Pierro DD, Tavazzi B, Lazzarino G, Giardina B (1992) Malondialdehyde is a biochemical marker of peroxidative damage in the isolated reperfused rat heart. Mol Cell Biochem 116: 193–196
Sandberg N (1962) Accelerated collagen formation and histamine. Nature 194: 183
Shore PA, Burkhalter A, Chon VH (1959) A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Therap 127: 182–186
Uchiyama M, Mihara M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86: 271–278
Wang O, Giri SN, Dallas MH, Nokashima JM (1989) Effects of taurine on bleomycininduced lung fibrosis in hamsters. Proc Soc Exp Biol Med 190: 330–338
White MJ, Heckler FR (1990) Oxygen free radicals and wound healing. Clin Plast Surg 17: 473–484
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dinçer, S., Babül, A., Erdoğan, D. et al. Effect of taurine on wound healing. Amino Acids 10, 59–71 (1996). https://doi.org/10.1007/BF00806093
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00806093