Summary
Respiratory sinus arrhythmia (RSA) has been traditionally defined as the high-frequency component of heart-rate fluctuations (HRF) synchronous with the respiratory movements (RM), i.e., the frequency of RSA corresponds to the respiration rate. It can be shown that at defined relations of mean heart and respiration rate some essential effects must be taken into consideration in studies using RSA parameters The relevance of these effects is shown and a new strategy of RSA quantification demanded, at least in neonates.
The diagnostic importance, physiological background and future application of the low-frequency components of the neonatal HRF are reviewed on the basis of our own results. Nonrespiratory cardiovascular HRF cannot always be detected in the neonate by power spectral analysis.
Movement-related HRF have a potential diagnostic importance per se, but may also artefactually disturb the quantification of other HRF components. Long-term trends can be used to describe sleep-state related trends and their disturbances.
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References
Akselrod S, Gordon D, Obel FA, Shannon DC, Borger K, Cohen RJ (1981) Power spectrum analysis of heart rate fluctuations: a quantitative probe of beat-to-beat, cardiovascular control. Science 213:220–222
Cabal LA, Goldberg RN, Hodgman JE, Siassi B, Zanini B, Plejsteck CE (1977) A primer of neonatal intensive care monitoring. I. Neonatal heart rate. William C. Moc Comp, North Haven
Clynes M (1960) Respiratory Sinus Arrhythmia: Laws derived from computer simulation. J Appl Physiol 15:863–875
Divon MY, Yeh S-Y, Zimmer EZ, Platt LD, Paldi E, Paul RH (1985) Respiratory Sinus Arrhythmia in the human fetus. Am J Obstet Gynecol 151:425–428
Divon MY, Winkler H, Yeh S-Y, Platt LD, Langer O, Merkatz IR (1986) Diminished Respiratory Sinus Arrhythmia in asphyxiated term infants. Am J Obstet Gynecol 155 (6):1263–1266
Eiselt M, Zweiner U, Wranek U, Rother M, Groß M, Heinz P (1989) Polygraphische Untersuchung von Risikoneugeborenen bei schwellennaher und überschwelliger akustischer Reizung. Z EEG-EMG 20:171–177
Erkinjuntti M, Kero P (1985) Heart rate response related to body movements in healthy and neurologically damaged infants during sleep. Early Human Development 12:31–37
Finley JP, Hamilton R, McKenzie MG (1984) Heart rate response to tilting in newborns in quiet and active sleep. Biol Neon 45:1–10
Hyndman BW, Kitney RI, Sayers BMA (1971) Spontaneous rhythms in physiological control systems. Nature 223:230–341
Kitney RI, Ong HG (1986) An analysis of cardiorespiratory control in babies and its relation to Sudden Infant Death Syndrome. Automedica 5:289–310
Kluge KA, Harper RM, Schechtman VL, Wilson AJ, Hoffmann HJ, Southhall DP (1988) Spectral analysis assessment of respiratory sinus arrhythmia in normal infants and infants who subsequently died of sudden infant death syndrome. Pediatr Res 24:677–682
Koepchen HP (1977) Neurophysiologische Grundlagen der nervösen Steuerung der Herzfrequenz, insbesondere ihrer atemrhythmischen Schwankungen. Medizin und Sport 17:136–140
Lindqvist A, Oja R, Hellman O, Välimäki I (1983) Impact of thermal vasomotor control on the heart rate variability of newborn infants. Early Human Development 8:37–47
Porges SW (1983) Heart rate patterns in neonates: a potential diagnostic window to the brain. In: Field T, Sostek A (eds) Infants born at risk. Physiological, perceptual and cognitive processes. Grune and Stratton, London New York, pp 3–22
Rompelman O, Pijnacker Horndijk WPh (1987) New methods for the assessment of neonatal respiratory sinus arrhythmia. Med Biol Eng Comput 25:481–486
Rother M, Zwiener U, Eiselt M, Witte H, Zwacka G, Frenzel J (1987) Differentiation of healthy newborns and newborns-at-risk by spectral analysis of heart rate fluctuations and respiratory movements. Early Human Development 15:349–363
Rother M, Zwiener U, Eiselt M, Witte H, Wagner H (1988) Objective characterization and differentiation of sleep states in healthy newborns and newborns-at-risk by spectral analysis of heart rate and respiration rhythms. Acta Physiologica Hungarica 73:383–393
Rother M, Witte H, Zwiener U, Eiselt M, Fischer P (1988) Cardiac aliasing — a possible cause for misinterpreting cardiorespirographic data in neonates. Early Human Development 20:1–12
Välimäki I, Anttila H, Antila K, Kero P (1980) Spectral analysis of neonatal heart rate. A preliminary report. In: Rolfe P (ed) Fetal and neonatal physiological measurement. Pitman. Oxford, pp 104–109
Ver Hoeve JN, Leavitt LA (1985) Neonatal acoustically-elicited cardiac response: Modulation by state and antecedent stimulation. Psychophysiology 22:231–236
Witte H, Rother M, Glaser S, Eiselt M (1987) Limitations and possibilities of demonstrating nonrespiratory cardiovascular heart-rate oscillations in newborn infants. A preliminary report. Automedica 9:231–233
Witte H (1988) Quantifizierung der Kopplung von spontanen Bewegungsfolgen und bewegungsabhängigen Herz- und Atemfrequenzreaktionen in der Neonatalperiode. Medizintechnik 28:38–42
Witte H, Liese F, Glaser S, Hoyer D (1988) Results of modelling and physiological examinations of movement related heart rate reactions. Med Biol Eng Comput 26:599–604
Witte H, Rother M (1989) A better quantification of neonatal respiratory sinus arrhythmia —progress by modelling and model-related physiological examinations. Med Biol Eng Comput 27:298–306
Witte H, Wagner H, Michels W (1988) The application of modelling to design a data processing system for the evaluation of the state dependence of selected parameters of transfer properties between respiratory movements and heart rate in neonates. A preliminary report. Syst Anal Model Simul 5:69–85
Witte H, Zwiener U, Glaser S, Rother M (1988) Evidence of a previously undescribed form of respiratory sinus arrhythmia (RSA) — the physiological manifestation of “cardiac aliasing”. Pflügers Arch 412:442–444
Wranek U, Zwiener U, Eiselt M, Wunder L, Bolwin R (1985) Vegetative Reflexe, EEG und partielle Arousalreaktion im schwellennahen Bereich auf akustische Reize bei Neugeborenen. Z EEG-EMG 16:120–123
Zwiener U, Glaser S (1984) A contribution to the functional organization of cardiovascular rhythms by their autospectral and coherence analysis. Automedica 5:277–288
Zwiener U, Witte H, Rother M, Wagner H, Eiselt M, Glaser S (1984) Sleep state related dynamics of neonatal heart rate fluctuations and respiration rhythms within several frequency ranges. Automedica 5:77–90
Zwiener U, Richter A, Schumann NP, Glaser S, Witte H (1987) Neurovegetative organization of heart rate rhythms and patterns in rabbits (in Russian). Fiziol Z SSSR 73:1650–1656
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Witte, H., Rother, M. High-frequency and low-frequency heart-rate fluctuation analysis in newborns—A review of possibilities and limitations. Basic Res Cardiol 87, 193–204 (1992). https://doi.org/10.1007/BF00801966
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DOI: https://doi.org/10.1007/BF00801966