Summary
Two primary spindle cell tumours of the thyroid are described showing light microscopic features of leiomyoma and neurilemoma respectively. The origin from smooth muscle and nerve sheath was confirmed by both immunohistochemical reactions and ultrastructural findings. Review of the literature reveals only one case of leiomyoma and three cases of neurilemoma reported as developing within the thyroid gland. Our observations further support the view that leiomyoma and neurilemoma may occur at this unusual site and are recognizable entities.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cramer SF, Meyer JS, Kraner JF, Camel M, Mazur MT, Tenenbaum MS (1980) Metastasizing leiomyoma of the uterus: S-phase fraction, estrogen receptor, and ultrastructure. Cancer 45:932–937
Delaney WE, Fry KE (1964) Neurilemoma of the thyroid gland. Ann Surg 160:1014–1016
Dickersin GR (1987) The electron microscopic spectrum of nerve sheath tumors. Ultrastruct Pathol 11:103–146
Du Boulay CEH (1985) Immunohistochemistry of soft tissue tumors: a review. J Pathol 146:77–94
Erlandsson RA (1985) Peripheral nerve sheath tumors. Ultrastruct Pathol 9:113–122
Goldstein J, Tovi F, Sidi J (1982) Primary schwannoma of the thyroid gland. Int Surg 67:433–434
Harkin JC, Reed RJ (1969) Tumors of the peripheral nervous system. Atlas of Tumor Pathology, 2nd series: Armed Forces Institute of Pathology, Washington, DC
Harris M (1981) Differential diagnosis of spindle cell tumours by electron microscopy. Personal experience and a review. Histopathology 5:81–105
Hendrick JW (1957) Leiomyoma of thyroid gland. Surgery 42:597–599
Hsu S-M, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique. A comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577–580
Kneeland-Frantz V (1962) Pathology of the thyroid. In: Werner SC (ed). The thyroid. Hoeber Medical Book, Harper and Row Publishers, New York, p 321
Meissner WA, Warren S (1968) Tumors of the thyroid gland. Atlas of Tumor Pathology, 2nd series. Armed Forces Institute of Pathology, Washington, DC
Nakajima T, Kameya T, Watanabe S, Hirota T, Sato Y, Shimosato Y (1982) An immunoperoxidase study of S-100 protein distribution in normal and neoplastic tissues. Am J Surg Pathol 6:715–727
Roholl PJM, De Jong ASH, Ramaekers FCS (1985) Application of markers in the diagnosis of soft tissue tumors. Histopathology 9:1019–1035
Rosai J (1981) Ackerman's Surgical Pathology. CV Mosby Company, St. Louis
Rosai J, Carcangiu ML (1987) Pitfalls in the diagnosis of thyroid neoplasms. Path Res Pract 182:169–179
Sobel HJ, Marquet E, Sobrinho-Simoes M, Johannesen JV (1981) Tumors and tumor-like conditions of soft tissues. In: Johannesen JV (ed) Electron microscopy in human medicine, vol. 4, Soft tissues, bones and joints. McGraw-Hill, New York, pp 143–256
Weiss SW, Langloss JM, Enzinger FM (1983) Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. Lab Invest 49:299–308
Author information
Authors and Affiliations
Additional information
This work was partly supported by a grant from the Italian M.P.I. (Rome) (Cap. no. 8551)
Rights and permissions
About this article
Cite this article
Andrion, A., Bellis, D., Delsedime, L. et al. Leiomyoma and neurilemoma: Report of two unusual non-epithelial tumours of the thyroid gland. Vichows Archiv A Pathol Anat 413, 367–372 (1988). https://doi.org/10.1007/BF00783030
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00783030