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SecB protein: A cytosolic export factor that associates with nascent exported proteins

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Abstract

Soluble factors participate in protein translocation across a variety of biological membranes. TheEscherichia coli soluble protein SecB (the product of thesecB gene) is involved in the export of periplasmic and outer membrane proteins. The isolation ofsecB mutations permitted the demonstration that SecB is required for rapid and efficient export of certain proteins. Consistent with the results of these genetic studies, purified SecB has been shown to stimulate protein translocation acrossE. coli inner membrane vesiclesin vitro. This article presents a review of these past studies of SecB, speculation on the role of SecB in protein translocation, and a comparison of SecB and other factors, trigger factor and GroEL.

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Authors and Affiliations

  1. Departments of Physiology and Molecular Biology-Microbiology, Tufts University School of Medicine, 02111, Boston, Massachusetts

    Carol A. Kumamoto

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  1. Carol A. Kumamoto
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Kumamoto, C.A. SecB protein: A cytosolic export factor that associates with nascent exported proteins. J Bioenerg Biomembr 22, 337–351 (1990). https://doi.org/10.1007/BF00763171

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  • DOI: https://doi.org/10.1007/BF00763171

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