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Developmental regulation of mitochondrial biogenesis inTrypanosoma brucei

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Abstract

The metabolism ofTrypanosoma brucei undergoes a significant change as the parasite differentiates from the mammalian bloodstream form to the form found in the tse-tse fly vector. Because the mitochondria of bloodstream form cells lack cytochromes and several key citric acid cycle enzymes, the metabolism of these cells is mostly limited to glycolysis. The reducing equivalents generated by this process are passed to oxygen by a plantlike alternative oxidase. As cells differentiate to the insect form, they begin to oxidatively metabolize proline. The mitochondria of insect form cells contain functional, cytochromemediated electron transport chains and have complete complements of citric acid cycle enzymes. Although the characterization is far from complete, the nuclear and mitochondrial genes involved in the expression of these mitochondrial functions appear to be developmentally regulated at posttranscriptional and posttranslational levels. This review outlines some of the molecular processes that are associated with the developmental regulation of mitochondrial biogenesis and suggests some possible mechanisms of regulation.

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  1. Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, 35294, Birmingham, Alabama

    Jeffrey W. Priest & Stephen L. Hajduk

  2. Department of Medicine, Schools of Medicine and Dentistry, University of Alabama at Birmingham, 35294, Birmingham, Alabama

    Stephen L. Hajduk

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Priest, J.W., Hajduk, S.L. Developmental regulation of mitochondrial biogenesis inTrypanosoma brucei . J Bioenerg Biomembr 26, 179–191 (1994). https://doi.org/10.1007/BF00763067

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