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Ascorbate on cell growth and differentiation

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Abstract

Ascorbate, an essential nutrient in humans, primates, and guinea pig, is involved in many cellular functions. Ascorbate also modulates cell growth and differentiation. Ascorbate can reduce or stimulate the growth of tumor cells, depending on the cell type. The inhibitory effect is not specific for the biological active isomerl-ascorbate, and isoascorbate andd-ascorbate are more effective in reducing cell growth thanl-ascorbate. These results indicate that ascorbate has a cytotoxic effect by killing cells directly, rather a cytostatic one. However, onlyl-ascorbate is able to stimulate cell growth, but the mechanism of this stimulation is still unknown.l-Ascorbate stimulates thein vitro differentiation of several mesenchyme-derived cell types by altering the expression of multiple genes as the cell progresses through specific differentiation programs. Stimulation of collagen matrix at gene transcription, mRNA stabilization, hydroxylation, and secretion is a key role forl-ascorbate.l-Ascorbate also prevents cell transformation by stabilization of the differentiated state and cooperates with other agents to induce differentiation in a leukemia cell line.

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  1. Departamento de Biología Celular, Facultad de Ciencias, Universidad de Córdoba, 14004, Córdoba, Spain

    Francisco J. Alcaín & M. Isabel Burón

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  1. Francisco J. Alcaín
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Alcaín, F.J., Burón, M.I. Ascorbate on cell growth and differentiation. J Bioenerg Biomembr 26, 393–398 (1994). https://doi.org/10.1007/BF00762780

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