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Functional sites in F1-ATPases: Location and interactions

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Abstract

This review focuses on the location and interaction of three functional sites in F1-ATPases. These are catalytic sites which are located in β subunits, noncatalytic nucleotide-binding sites which are located at interfaces of α and β subunits and modulate the hydrolytic activity of the enzyme, and a site that binds inhibitory amphipathic cations which is at an interface of α and β subunits. The latter site may participate in transmission of conformational signals between catalytic sites in F1 and the proton-conducting apparatus of F0 in the intact ATP synthases.

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Authors and Affiliations

  1. Department of Chemistry, University of California at San Diego, 92093-0601, La Jolla, California

    William S. Allison, Jean-Michel Jault, Shaoqiu Zhuo & Seung R. Paik

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  1. William S. Allison
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  2. Jean-Michel Jault
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  3. Shaoqiu Zhuo
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Allison, W.S., Jault, JM., Zhuo, S. et al. Functional sites in F1-ATPases: Location and interactions. J Bioenerg Biomembr 24, 469–477 (1992). https://doi.org/10.1007/BF00762364

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