Conclusions
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1.
A convenient method for producing octahydroacridine by reduction of the tetrahydro-derivatives with concentrated formic acid was developed.
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2.
Trans-10-γ-dimethyl- and 10-γ-methyl- and cis-10-γ-dimethylaminopropyl derivatives of 1,2,3, 4,4a,9,9a,10-octahydroacridine were synthesized and isolated in the form of the maleates.
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3.
It was shown that the compounds obtained possess a number of pharmacological properties, characteristic of imizine (imipramine) and other tricyclic antidepressants.
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4.
No significant difference was detected in the activities of the cis-and trans-isomers. Trans-10-methylaminopropyl-l,2,3,4,4a,9,9a,10-octahydroacridine is somewhat less active and toxic than the dimethyl analog corresponding to it.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 6, pp. 20–23, June, 1968.
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Ermolaeva, V.G., Yashunskii, V.G., Polezhaeva, A.I. et al. Synthesis and pharmacological properties of certain derivatives of octahydroacridines. Pharm Chem J 2, 310–312 (1968). https://doi.org/10.1007/BF00759725
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DOI: https://doi.org/10.1007/BF00759725