Abstract
8-Hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) has been reported to increase food intake. This effect was confirmed in rats consuming plain or sweetened wet mash. However, the consumption of a 35% sucrose solution or of a range of other flavoured liquids was enhanced marginally if at all by a single low dose of 8-OH-DPAT, and the drug actually decreased the consumption of a high protein liquid diet. 8-OH-DPAT did, however, increase gnawing on a wooden block. These results suggest that 8-OH-DPAT-induced “hyperphagia” may to some extent be secondary to the elicitation of chewing behaviour. 8-OH-DPAT also caused certain other behavioural changes, including a suppression of grooming.
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Ahlenius S, Larsson K, Svensson L, Hjorth S, Carlsson A, Lindberg P, Wikstrom H, Sanchez D, Arvidsson L-E, Hacksell U, Nilsson JLG (1981) Effects of a new type of 5-HT agonist on male sexual behaviour. Pharmacol Biochem Behav 15:785–792
Antin J, Gibbs J, Holt J, Young RC, Smith GP (1975) Cholecystokinin elicits the complete behavioural sequence of satiety in rats. J Comp Physiol Psychol 89:784–790
Arvidsson L-E, Hacksell U, Nilsson JLG, Hjorth S, Carlsson A, Lindberg P, Sanchez D, Wikstrom H (1981) 8-Hydroxy-2-(di-n-propylamino) tetralin, a new centrally acting 5-HT receptor agonist. J Med Chem 24:921–923
Cofer CN (1972) Motivation and emotion. Foresman, London
Coughlan J, Dourish CT, Gilbert F, Iversen SD (1987) The 5-TH1A agonist 8-OH-DPAT increases sweetened milk consumption in rats. Br J Pharmacol (in press)
Dourish CJ, Hutson PH, Curzon G (1985a) Low doses of the putative serotonin agonist 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat. Psychopharmacology 86:197–204
Dourish CJ, Hutson PH, Curzon G (1985b) Characteristics of feeding induced by the serotonin agonist 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT). Brain Res Bull 15:377–384
Dourish CJ, Hutson PH, Curzon G (1986a) Para-chlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Psychopharmacology 89:467–471
Dourish CJ, Hutson PH, Kennett GA, Curzon G (1986b) 8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance. Appetite [Suppl] 7:127–140
Engel JA (1986) Anticonflict effect of the putative serotonin receptor agonist 8-OH-DPAT. Paper presented at the European Behavioural Pharmacology Society, Antwerp, July 1986. Psychopharmacology (Abstr) 89:S28
Engel JA, Hjorth S, Svensson K, Carlsson A, Liljequist S (1984) Anticonflict effect of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Eur J Pharmacol 105:365–368
Fletcher P (1987) 8-OH-DPAT elicits gnawing and eating of solid but not liquid foods. Psychopharmacology 92:192–195
Gozlan H, El Mestikaway S, Pichat L, Glowinski J, Hamon M (1983) Identification of presynaptic serotonin autoreceptors using a new ligand:3H-PAT. Nature 305:140–142
Hjorth S, Carlsson A, Lindberg P, Sanchez D, Wikstrom H, Arvidsson L-E, Hacksell U, Nilsson JLG (1982) 8-Hydroxy-2-(di-n-propylamino) tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT receptor stimulating activity. J Neural Transm 55:169–188
Kushner LR, Mook DG (1984) Behavioural correlations of oral and post-ingestive satiety in the rat. Physiol Behav 33:713–718
Larson AA, Kondzielska MH (1982) Serotonin-induced gnawing in rats: Comparison with tail pinch-induced gnawing. Pharmacol Biochem Behav 16:407–409
Middlemiss DN, Fozard JR (1983) 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between sub-types of the 5-HT1 recognition site. Eur J Pharmacol 90:151–153
Peroutka SJ (1985) Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors. Biol Psychiatry 20:971–979
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Montgomery, A.M.J., Willner, P. & Muscat, R. Behavioural specificity of 8-OH-DPAT-induced feeding. Psychopharmacology 94, 110–114 (1988). https://doi.org/10.1007/BF00735890
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DOI: https://doi.org/10.1007/BF00735890