Abstract
The 5-HT1A agonist 8-OH-DPAT, at a dose of 30 μg/kg, enhanced the consumption of sweetened wet mash and sweetened milk in non-deprived rats. In partially satiated rats, sensitivity to the hyperphagic effect of 8-OH-DPAT on wet mash intake was substantially increased, so that the minimally effective dose was reduced to 3 μg/kg. Similarly, 8-OH-DPAT was more efficacious in increasing milk intake in satiated rats. Thus, 30 and 40 μg/kg 8-OH-DPAT produced a 4-fold increase of milk intake in completely satiated rats compared to a 2-fold increase in partially satiated animals at a dose of 30 μg/kg. The increased intake of liquid and wet mash diets observed after treatment with low doses of 8-OH-DPAT argues against the involvement of non-specific gnawing in the increased consumption of solid food produced by the drug. Rather, the data suggest that 8-OH-DPAT may specifically stimulate appetite by counteracting a tonic serotonergic inhibition of feeding. The present experiments also showed that 8-OH-DPAT attenuates fenfluramine-induced anorexia which is thought to depend on increased serotonergic neurotransmission.
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Amsterdam JD, Berwish N, Potter L, Rickels K (1987) Open trial of gepirone in the treatment of major depressive disorder. Curr Ther Res 41:185–193
Blundell JE (1977) Is there a role for serotonin (5-hydroxytryptamine) in feeding? Int J Obes 1:15–42
Blundell JE (1984) Serotonin and appetite. Neuropharmacology 23:1537–1551
Burton MJ, Cooper SJ, Popplewell DA (1984) The effect of fenfluramine on the microstructure of feeding and drinking in the rat. Br J Pharmacol 69:621–633
Cooper SJ (1986) Hyperphagic and anoretic effects of β-carbolines in a palatable food consumption test: comparisons with triazolam and quazepam. Eur J Pharmacol 120:257–265
Cooper SJ (1987) Palatability-induced food consumption is stimulated by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) In: Dourish CT, Ahlenius S, Hutson PH (eds) Brain 5-HT1A receptors: behavioural and neurochemical pharmacology. Ellis Horwood, Chichester (in press)
Cooper SJ, Francis RL (1980) Interactions of chlordiazepoxide and anorectic agents on rate and duration parameters of feeding in the rat. Psychopharmacology 69:261–265
Cooper SJ, Neill JC (1987) Sham feeding in the rat following the administration of (+)—fenfluramine and the putative 5-HT1A agonist 8-OH-DPAT. Br J Pharmacol 91:339P
Cooper SJ, Barber DJ, Gilbert DB, Moores WR (1985) Benzodiazepine receptor ligands and the consumption of a highly palatable diet in non-deprived male rats. Psychopharmacology 86:348–355
Dourish CT, Gilbert F (1987) Interactions between 5-HT1A agonists on food intake in rats. Br J Pharmacol 91:425P
Dourish CT, Hutson PH, Curzon G (1985a) Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat. Psychopharmacology 86:197–204
Dourish CT, Hutson PH, Curzon G (1985b) Characteristics of feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Brain Res Bull 15:377–384
Dourish CT, Hutson PH, Kennett GA, Curzon G (1986a) 8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance. Appetite [Suppl] 7:127–140
Dourish CT, Hutson PH, Curzon G (1985b) Para-chlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Psychopharmacology 89:467–471
Dourish CT, Hutson PH, Curzon G (1986c) Putative anxiolytics 8-OH-DPAT, buspirone and TVX Q 7821 are agonists at 5-HT1A autoreceptors in the raphe nuclei. TIPS 7:212–214
Fletcher PJ (1987) 8-OH-DPAT elicits gnawing and eating of solid but not liquid foods. Psychopharmacology 92:192–195
Garattini S, Borroni E, Mennini T, Samanin R (1978) Differences and similarities among anorectic agents. In: Garattini S, Sananin R (eds) Central mechanisms of anorectic drugs. Raven, New York, pp 127–143
Hutson PH, Dourish CT, Curzon G (1986) Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors. Eur J Pharmacol 129:347–352
Middlemiss DN, Fozard JR (1983) 8-Hydroxy-2-(di-n-propylamino) tetralin discriminates between subtypes of the 5-HT1 recognition site. Eur J Pharmacol 90:151–153
Montgomery AMJ, Willner P, Muscat R (1987) Behavioural specificity of 8-OH-DPAT-induced feeding. Psychopharmacology (in press)
Neill J, Cooper SJ (1987) MDL 72832, a novel 5-HT1A receptor ligand, stereoselectively stimulates palatable food consumption in rats. Br J Pharmacol (in press)
Nicolaidis S (1986) (ed) Serotonergic system, feeding and body weight regulation. Academic London
Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill, New York
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Dourish, C.T., Cooper, S.J., Gilbert, F. et al. The 5-HT1A agonist 8-OH-DPAT increases consumption of palatable wet mash and liquid diets in the rat. Psychopharmacology 94, 58–63 (1988). https://doi.org/10.1007/BF00735881
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DOI: https://doi.org/10.1007/BF00735881